| Entry |
|
| Name |
L-threonine 3-dehydrogenase;
L-threonine dehydrogenase;
threonine 3-dehydrogenase;
threonine dehydrogenase;
TDH
|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
| Sysname |
L-threonine:NAD+ oxidoreductase
|
| Reaction(IUBMB) |
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+ [RN: R01465]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
This enzyme acts in concert with EC 2.3.1.29, glycine C-acetyltransferase, in the degradation of threonine to glycine. This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex [2]. In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.
|
| Pathway |
| Glycine, serine and threonine metabolism |
|
| Orthology |
| threonine 3-dehydrogenase | | threonine 3-dehydrogenase |
|
| Genes |
PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | NVE: | | HMG: | | TAD: | | CME: | | NGR: | | PIF: | | ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | EBT: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | EBI: | | PLU: | | PAY: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PMR: | | EIC: | | ETR: | | ETD: | | ETC: | | DDA: | | DDC: | | DDD: | | DZE: | | XBO: | | XNE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | PSI: | | ROR: | | EBF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | FAU: | | RHD: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | VFI: | | VFM: | | VSA: | | PPR: | | VAN: | | SON: | | SDN: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SBT: | | SBS: | | SBB: | | SLO: | | SPC: | | SHP: | | SSE: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | SVO: | | ILO: | | CPS: | | PHA: | | PAT: | | PSM: | | AMC: | | AMAC: | | AMB: | | AMG: | | AMK: | | AMAA: | | ALT: | | GAG: | | GNI: | | GPS: | | PIN: | | PSY: | | FBL: | | CBU: | | CBS: | | CBD: | | CBG: | | CBC: | | LPN: | | LPU: | | LPF: | | LPP: | | LPC: | | LPA: | | LPE: | | LLO: | | FTU: | | FTF: | | FTW: | | FTR: | | FTT: | | FTG: | | FTL: | | FTH: | | FTA: | | FTS: | | FTI: | | FTM: | | FTN: | | FCF: | | FCN: | | FPH: | | FRT: | | FNA: | | HCH: | | KKO: | | MMW: | | MME: | | MPC: | | AHA: | | ASA: | | AVR: | | OCE: | | SAGA: | | CVI: | | PSE: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPZ: | | BPQ: | | BTE: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BRH: | | BGD: | | BYI: | | BUK: | | BPX: | | PUT: | | DAC: | | CTT: | | TMZ: | | GBM: | | GEM: | | GEB: | | DSA: | | DHY: | | DBA: | | DTO: | | ADE: | | ACP: | | AFW: | | ANK: | | SCL: | | DTI: | | MLO: | | MCI: | | MOP: | | MAM: | | MES: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | SFD: | | ARA: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | PHL: | | BSB: | | SIL: | | SIT: | | RSP: | | RSH: | | RSQ: | | RSK: | | RDE: | | RLI: | | PGA: | | PGL: | | MMR: | | PBR: | | MAI: | | MAN: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAMI: | | BAE: | | BPU: | | BSE: | | BCO: | | BJS: | | HHD: | | ESI: | | EAT: | | EAN: | | STH: | | DOR: | | TTE: | | TEX: | | THX: | | TPD: | | TBO: | | TWI: | | TEP: | | TAE: | | CPO: | | NTH: | | ASD: | | GOR: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SCT: | | SCY: | | SFA: | | SHY: | | SHO: | | SVE: | | SDV: | | STRP: | | KSK: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | BCV: | | BFA: | | KSE: | | ICA: | | PAC: | | PAK: | | PAV: | | PAX: | | PAZ: | | PAW: | | PAD: | | PCN: | | PACC: | | PACH: | | PPC: | | PBO: | | PRA: | | MPH: | | NCA: | | KFL: | | SRO: | | NML: | | GOB: | | SEN: | | AMI: | | SESP: | | AHE: | | CWO: | | PCU: | | PUV: | | WCH: | | SCD: | | ABA: | | ACA: | | ACM: | | GMA: | | TSA: | | SUS: | | PPN: | | RMR: | | RMG: | | PHE: | | OTE: | | AMU: | | GAU: | | PSL: | | PLM: | | PBS: | | IPA: | | EMI: | | IAL: | | HAU: | | DRA: | | DGE: | | DDR: | | DMR: | | DPT: | | DGO: | | DPD: | | TTH: | | TTJ: | | TTS: | | TTL: | | TSC: | | THC: | | TOS: | | OPR: | | MHD: | | TLE: | | TTA: | | TME: | | TAF: | | FNO: | | FPE: | | PMO: | | KOL: | | MPZ: | | MPG: | | NDE: | | CEX: | | HVO: | | PHO: | | PAB: | | PFU: | | PFI: | | PYN: | | PYA: | | PYS: | | TKO: | | TON: | | TGA: | | TSI: | | TBA: | | THE: | | THA: | | THM: | | » show all
 |
| Reference |
|
| Authors |
Green ML, Elliott WH. |
| Title |
The enzymic formation of aminoacetone from threonine and its further metabolism. |
| Journal |
Biochem. J. 92 (1964) 537-49. |
| Organism |
Rattus norvegicus [GN: rno], Staphylococcus aureus, Oryctolagus cuniculus |
| Reference |
|
| Authors |
HARTSHORNE D, GREENBERG DM. |
| Title |
STUDIES ON LIVER THREONINE DEHYDROGENASE. |
| Journal |
Arch. Biochem. Biophys. 105 (1964) 173-8. |
| Organism |
Rana catesbeiana |
| Reference |
|
| Authors |
Newman EB, Kapoor V, Potter R. |
| Title |
Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli. |
| Journal |
J. Bacteriol. 126 (1976) 1245-9. |
| Organism |
Escherichia coli [GN: eco] |
| Reference |
|
| Authors |
Epperly BR, Dekker EE. |
| Title |
L-threonine dehydrogenase from Escherichia coli. Identification of an active site cysteine residue and metal ion studies. |
| Journal |
J. Biol. Chem. 266 (1991) 6086-92. |
| Organism |
Escherichia coli [GN: eco] |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9067-99-6 |