KEGG   ENZYME: 1.1.1.127Help
Entry
EC 1.1.1.127                Enzyme                                 

Name
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase;
2-keto-3-deoxygluconate 5-dehydrogenase;
2-keto-3-deoxy-D-gluconate dehydrogenase;
2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase;
2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase
Reaction(IUBMB)
2-dehydro-3-deoxy-D-gluconate + NAD+ = (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H+ [RN:R01542]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-D-gluconate [CPD:C00204];
NAD+ [CPD:C00003]
Product
(4S)-4,6-dihydroxy-2,5-dioxohexanoate [CPD:C04349];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Pseudomonas acts equally well on NAD+ or NADP+, while that from Erwinia chrysanthemi and Escherichia coli is more specific for NAD+.
History
EC 1.1.1.127 created 1972, modified 1976, modified 1989
Pathway
Pentose and glucuronate interconversions
Reference
1
  Authors
Condemine, G., Hugouvieux-Cotte-Pattat, N. and Robert-Baudouy, J.
  Title
An enzyme in the pectolytic pathway of Erwinia chrysanthemi: 3-keto-3-deoxygluconate oxidoreductase.
  Journal
J. Gen. Microbiol. 130 (1984) 2839-2844.
Reference
2  [PMID:13986017]
  Authors
PREISS J, ASHWELL G.
  Title
Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2, 5-hexodiulosonic acid.
  Journal
J. Biol. Chem. 238 (1963) 1577-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-56-9

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