KEGG   ENZYME: 1.1.1.130Help
Entry
EC 1.1.1.130                Enzyme                                 

Name
3-dehydro-L-gulonate 2-dehydrogenase;
3-keto-L-gulonate dehydrogenase;
3-ketogulonate dehydrogenase;
3-keto-L-gulonate dehydrogenase;
3-ketogulonate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+ [RN:R02637 R02639]
Reaction(KEGG)
Substrate
3-dehydro-L-gulonate [CPD:C00618];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
(4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate [CPD:C04575];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.130 created 1972
Pathway
ec00040  Pentose and glucuronate interconversions
ec00053  Ascorbate and aldarate metabolism
Orthology
K08092  3-dehydro-L-gulonate 2-dehydrogenase
Genes
ECO: b3575(yiaK)
ECJ: JW3547(yiaK)
ECD: ECDH10B_3756(yiaK)
EBW: BWG_3265(yiaK)
ECOK: ECMDS42_3012(yiaK)
EOJ: ECO26_5026(yiaK)
EOI: ECO111_4395(yiaK)
EOH: ECO103_4659(yiaK)
ECG: E2348C_3827(yiaK)
ECC: c4396(yiaK)
ECP: ECP_3679
ECI: UTI89_C4117(yiaK)
ECV: APECO1_2875(yiaK)
ECX: EcHS_A3779(dlgD)
ECW: EcE24377A_4072(dlgD)
ECM: EcSMS35_3898(dlgD)
ECY: ECSE_3851
ECR: ECIAI1_3742(yiaK)
ECQ: ECED1_4263(yiaK)
ECK: EC55989_4032(yiaK)
ECT: ECIAI39_4087(yiaK)
EOC: CE10_4129(yiaK)
EUM: ECUMN_4088(yiaK)
ECZ: ECS88_3994(yiaK)
ELO: EC042_3881(dlgD)
ELH: ETEC_3818
ESE: ECSF_3410
ESO: O3O_24700
ESM: O3M_01005
ESL: O3K_00975
EBR: ECB_03427(yiaK)
EBD: ECBD_0159
EKF: KO11_04845(yiaK)
EAB: ECABU_c40180(dlgD)
EDJ: ECDH1ME8569_3456(yiaK)
EIH: ECOK1_4022(dlgD)
ENA: ECNA114_3727(yiaK)
ELW: ECW_m3849(yiaK)
ELL: WFL_18795(yiaK)
ELC: i14_4063(yiaK)
ELD: i02_4063(yiaK)
ELP: P12B_c3704(yiaK)
EBL: ECD_03427(yiaK)
EBE: B21_03378(yiaK)
ELF: LF82_3339(yiaK)
ECOI: ECOPMV1_03913(dlgD)
ECOJ: P423_19890
ECOS: EC958_3982(yiaK)
EFE: EFER_3573(yiaK)
STY: STY4130
STT: t3851
STM: STM3668(yiaK)
SEO: STM14_4425(yiaK)
SEY: SL1344_3633(yiaK)
SEJ: STMUK_3654(yiaK)
SEB: STM474_3840(yiaK)
SENI: CY43_19040
SPT: SPA3519(yiaK)
SEK: SSPA3286
SEI: SPC_3748(yiaK)
SHB: SU5_04145
SENS: Q786_17920
SED: SeD_A4053
SEG: SG3763(yiaK)
SEL: SPUL_3897(yiaK)
SEGA: SPUCDC_3883(yiaK)
SET: SEN3490(yiaK)
SENA: AU38_17830
SENO: AU37_18020
SENV: AU39_18025
SENQ: AU40_20080
SENL: IY59_18465
SEEP: I137_18700
SENE: IA1_17815
SFL: SF3619(yiaK)
SFX: S4150(yiaK)
SFV: SFV_3965(yiaK)
SFE: SFxv_3943(yiaK)
SFN: SFy_5156
SFS: SFyv_5232
SFT: NCTC1_03914(yiaK)
SBO: SBO_3583(yiaK)
SBC: SbBS512_E3947(dlgD)
ENC: ECL_00191
ECLO: ENC_47440
EEC: EcWSU1_00160(dlgD)
ECLX: LI66_21885
ECLY: LI62_23905
ENF: AKI40_2078(yiaK)
KPE: KPK_0166(dlgD)
KOX: KOX_05675
KOE: A225_5605
CKO: CKO_05033
EBF: D782_0150
YIN: CH53_4238(dlgD)
SPE: Spro_3933
SRL: SOD_c38930(dlgD)
SPLY: Q5A_020880(dlgD)
SMAC: SMDB11_3331(dlgD)
RAA: Q7S_05145
PCT: PC1_3692
PEC: W5S_4035
SOD: Sant_1948
PAM: PANA_0364(dlgD)
PLF: PANA5342_4050(dlgD)
PAJ: PAJ_3520(dlgD)
PSTW: DSJ_03410
HIN: HI1031
HAP: HAPS_1811
HPAZ: K756_12020
HPAK: JT17_07790
HSO: HS_0759(mdh)
HSM: HSM_1226
PMU: PM1256
PMV: PMCN06_1920(dlgD)
PMP: Pmu_19160(dlgD)
PMUL: DR93_499(dlgD)
MSU: MS0054
MHT: D648_390
MHQ: D650_370
MHAT: B824_1140
MHX: MHH_c05720(dlgD)
MHAE: F382_07945
MHAM: J450_07145
MHAO: J451_08025
MHAL: N220_00120
MHAQ: WC39_00180
MHAY: VK67_00185
MVR: X781_670
MVI: X808_820
MVG: X874_790
APL: APL_1573
APA: APP7_1635
ASU: Asuc_0268
BTO: WQG_22320
BTRE: F542_290
BTRH: F543_300
BTRA: F544_22850
VSP: VS_II0146
BCT: GEM_3243
CBEI: LF65_03926
CPAS: Clopa_1614
CPAT: CLPA_c27020(dlgD)
CPAE: CPAST_c27020(dlgD)
CPY: Cphy_1597
APR: Apre_0576
PUF: UFO1_3871
APAL: BN85403770
ACA: ACP_1954
GBA: J421_0713
PHE: Phep_3438
MUC: MuYL_3799
MGOT: MgSA37_04096(dlgD)
MARM: YQ22_10005
AALG: AREALGSMS7_03762(dlgD)
MRO: MROS_2339
 » show all
Taxonomy
Reference
1  [PMID:13926592]
  Authors
VOLK WA, LARSEN JL.
  Title
beta-Keto-L-gulonic acid as an intermediate in the bacterial metabolism of ascorbic acid.
  Journal
J. Biol. Chem. 237 (1962) 2454-7.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.130
IUBMB Enzyme Nomenclature: 1.1.1.130
ExPASy - ENZYME nomenclature database: 1.1.1.130
BRENDA, the Enzyme Database: 1.1.1.130
CAS: 37250-61-6

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