KEGG   ENZYME: 1.1.1.148Help
Entry
EC 1.1.1.148                Enzyme                                 

Name
estradiol 17alpha-dehydrogenase;
17alpha-estradiol dehydrogenase;
17alpha-hydroxy steroid dehydrogenase;
17alpha-hydroxy steroid oxidoreductase;
17alpha-hydroxysteroid oxidoreductase;
estradiol 17alpha-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase
Reaction(IUBMB)
estradiol-17alpha + NAD(P)+ = estrone + NAD(P)H + H+ [RN:R02347 R02349]
Reaction(KEGG)
Substrate
estradiol-17alpha [CPD:C02537];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
estrone [CPD:C00468];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.148 created 1972
Pathway
Steroid hormone biosynthesis
Reference
1  [PMID:4383682]
  Authors
Renwick AG, Engel LL.
  Title
The partial purification of 17 alpha- and 17 beta-estradiol dehydrogenase activities from chicken liver.
  Journal
Biochim. Biophys. Acta. 146 (1967) 336-48.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9044-91-1

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