KEGG   ENZYME: 1.1.1.149Help
Entry
EC 1.1.1.149                Enzyme                                 

Name
20alpha-hydroxysteroid dehydrogenase;
20alpha-hydroxy steroid dehydrogenase;
20alpha-HSD;
20alpha-HSDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
Reaction(IUBMB)
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ [RN:R03325]
Reaction(KEGG)
Substrate
17alpha,20alpha-dihydroxypregn-4-en-3-one [CPD:C04518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
17alpha-hydroxyprogesterone [CPD:C01176];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase).
History
EC 1.1.1.149 created 1972, deleted 1983, reinstated 1986
Pathway
Steroid hormone biosynthesis
Orthology
K00212  
20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
K05295  
20alpha-hydroxysteroid dehydrogenase
Genes
HSA: 
1645(AKR1C1)
PTR: 
100607996(AKR1C1)
PPS: 
100986729(AKR1C1)
PON: 
100171658(AKR1C1)
NLE: 
100605934(AKR1C1)
MCC: 
711198(AKR1C1)
MCF: 
101865536(AKR1C1)
CSAB: 
RRO: 
CJC: 
100404656(AKR1C1)
SBQ: 
MMU: 
105349(Akr1c18)
RNO: 
171516(Akr1c3)
CGE: 
HGL: 
 » show all
Taxonomy
Reference
1  [PMID:4382486]
  Authors
Shikita M, Inano H, Tamaoki B.
  Title
Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes.
  Journal
Biochemistry. 6 (1967) 1760-4.
Reference
2  [PMID:6935192]
  Authors
Strickler RC, Tobias B, Covey DF.
  Title
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.
  Journal
J. Biol. Chem. 256 (1981) 316-21.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9040-08-8

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