KEGG   ENZYME: 1.1.1.151Help
Entry
EC 1.1.1.151                Enzyme                                 

Name
21-hydroxysteroid dehydrogenase (NADP+);
21-hydroxy steroid dehydrogenase;
21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase;
21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate);
NADP+-21-hydroxysteroid dehydrogenase;
21-hydroxysteroid dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
21-hydroxysteroid:NADP+ 21-oxidoreductase
Reaction(IUBMB)
pregnan-21-ol + NADP+ = pregnan-21-al + NADPH + H+ [RN:R03044]
Reaction(KEGG)
Substrate
pregnan-21-ol [CPD:C00892];
NADP+ [CPD:C00006]
Product
pregnan-21-al [CPD:C00891];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a number of 21-hydroxycorticosteroids.
History
EC 1.1.1.151 created 1972
Reference
1  [PMID:14253469]
  Authors
MONDER C, WHITE A.
  Title
THE 21-HYDROXYSTEROID DEHYDROGENASES OF LIVER. A NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE AND TWO NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASES.
  Journal
J. Biol. Chem. 240 (1965) 71-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-76-3

DBGET integrated database retrieval system