KEGG   ENZYME: 1.1.1.16Help
Entry
EC 1.1.1.16                 Enzyme                                 

Name
galactitol 2-dehydrogenase;
dulcitol dehydrogenase;
AtuSorbD (gene name);
galactitol:NAD+ 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
galactitol:NAD+ 2-oxidoreductase (D-tagatose-forming)
Reaction(IUBMB)
galactitol + NAD+ = D-tagatose + NADH + H+ [RN:R02928]
Reaction(KEGG)
Substrate
galactitol [CPD:C01697];
NAD+ [CPD:C00003]
Product
D-tagatose [CPD:C00795];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.
History
EC 1.1.1.16 created 1961
Pathway
ec00052  Galactose metabolism
Orthology
K21620  galactitol 2-dehydrogenase
Genes
PHD: 102330493
PFS: PFLU_2474(polS)
PTV: AA957_02490
PSK: U771_12995
MAMO: A6B35_14975
MESO: BSQ44_18575
MES: Meso_3781
HOE: IMCC20628_00250
SME: SMc01500(smoS)
SMK: Sinme_2489
SMX: SM11_chr2594(smoS)
SMI: BN406_02290(polS)
SMEL: SM2011_c01500(smoS)
SMER: DU99_13605
SIX: BSY16_5965(polS)
EAD: OV14_a1806(smoS)
ATU: Atu3164
AVI: Avi_3571
RET: RHE_PC00218(smoS)
REL: REMIM1_PB00223(polS)
REI: IE4771_PE00688(polS)
REP: IE4803_PD00664(polS)
RIR: BN877_II0150(polS)
RHN: AMJ98_PB00289(polS)
SHZ: shn_04565
OAN: Oant_3850
OAH: DR92_2641(polS)
RSP: RSP_0095(smoS)
PGA: PGA1_c13170(polS)
PGL: PGA2_c13120(polS)
PGD: Gal_02087
PHP: PhaeoP97_01314(polS)
AZL: AZL_b04800(gutB)
 » show all
Taxonomy
Reference
1  [PMID:13373783]
  Authors
SHAW DR.
  Title
Polyol dehydrogenases.  3.  Galactitol dehydrogenase and D-iditol dehydrogenase.
  Journal
Biochem. J. 64 (1956) 394-405.
Reference
2  [PMID:26472925]
  Authors
Wichelecki DJ, Vetting MW, Chou L, Al-Obaidi N, Bouvier JT, Almo SC, Gerlt JA
  Title
ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.
  Journal
J. Biol. Chem. 290 (2015) 28963-76.
  Sequence
[atu:Atu3164]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.16
IUBMB Enzyme Nomenclature: 1.1.1.16
ExPASy - ENZYME nomenclature database: 1.1.1.16
BRENDA, the Enzyme Database: 1.1.1.16
CAS: 9028-23-3

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