KEGG   ENZYME: 1.1.1.16Help
Entry
EC 1.1.1.16                 Enzyme                                 

Name
galactitol 2-dehydrogenase;
dulcitol dehydrogenase;
AtuSorbD (gene name);
galactitol:NAD+ 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
galactitol:NAD+ 2-oxidoreductase (D-tagatose-forming)
Reaction(IUBMB)
galactitol + NAD+ = D-tagatose + NADH + H+ [RN:R02928]
Reaction(KEGG)
Substrate
galactitol [CPD:C01697];
NAD+ [CPD:C00003]
Product
D-tagatose [CPD:C00795];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.
History
EC 1.1.1.16 created 1961
Pathway
Galactose metabolism
Orthology
K21620  
galactitol 2-dehydrogenase
Genes
PHD: 
PFS: 
PFLU_2474(polS)
PTV: 
PSK: 
MAMO: 
MESO: 
MES: 
HOE: 
SME: 
SMc01500(smoS)
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMER: 
SIX: 
EAD: 
ATU: 
ATF: 
AVI: 
AGR: 
ARO: 
RET: 
REL: 
REI: 
REP: 
RIR: 
RHN: 
SHZ: 
OAN: 
OAH: 
DR92_2641(polS)
OPS: 
CHEL: 
AUA: 
RSP: 
RSP_0095(smoS)
RSH: 
RSK: 
PGA: 
PGL: 
PGD: 
PHP: 
PPHR: 
LAP: 
LAGG: 
AZL: 
ATI: 
 » show all
Taxonomy
Reference
1  [PMID:13373783]
  Authors
SHAW DR.
  Title
Polyol dehydrogenases.  3.  Galactitol dehydrogenase and D-iditol dehydrogenase.
  Journal
Biochem. J. 64 (1956) 394-405.
Reference
2  [PMID:26472925]
  Authors
Wichelecki DJ, Vetting MW, Chou L, Al-Obaidi N, Bouvier JT, Almo SC, Gerlt JA
  Title
ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel d-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.
  Journal
J. Biol. Chem. 290 (2015) 28963-76.
  Sequence
[atu:Atu3164]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-23-3

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