Entry |
|
Name |
dihydrobunolol dehydrogenase;
bunolol reductase
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
Sysname |
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase
|
Reaction(IUBMB) |
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH + H+ [RN: R04623]
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Reaction(KEGG) |
|
Substrate |
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol [CPD: C04875];
NADP+ [CPD: C00006]
|
Product |
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone [CPD: C04883];
NADPH [CPD: C00005];
H+ [CPD: C00080]
|
Comment |
Also acts, more slowly, with NAD+.
|
History |
EC 1.1.1.160 created 1976
|
Reference |
|
Authors |
Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ. |
Title |
Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol. |
Journal |
Xenobiotica. 2 (1972) 191-202. |
Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 62213-61-0 |