KEGG   ENZYME: 1.1.1.160Help
Entry
EC 1.1.1.160                Enzyme                                 

Name
dihydrobunolol dehydrogenase;
bunolol reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase
Reaction(IUBMB)
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH + H+ [RN:R04623]
Reaction(KEGG)
Substrate
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol [CPD:C04875];
NADP+ [CPD:C00006]
Product
(+/-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone [CPD:C04883];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, with NAD+.
History
EC 1.1.1.160 created 1976
Reference
1  [PMID:4560367]
  Authors
Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ.
  Title
Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol.
  Journal
Xenobiotica. 2 (1972) 191-202.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62213-61-0
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