KEGG   ENZYME: 1.1.1.165Help
Entry
EC 1.1.1.165                Enzyme                                 

Name
2-alkyn-1-ol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-butyne-1,4-diol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + NADH + H+ [RN:R03963]
Reaction(KEGG)
Substrate
2-butyne-1,4-diol [CPD:C02497];
NAD+ [CPD:C00003]
Product
4-hydroxy-2-butynal [CPD:C02648];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Acts on a variety of 2-alkyn-1-ols, and also on 1,4-butanediol. NADP+ also acts as acceptor, but more slowly.
History
EC 1.1.1.165 created 1976
Reference
1
  Authors
Miyoshi, T., Sato, H. and Harada, T.
  Title
Purification and characterization of 2-alkyne-1-ol dehydrogenase induced by 2-butene-1,4-diol in Fusarium merismoides B11.
  Journal
Biochim. Biophys. Acta 358 (1974) 231-239.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
54576-94-2

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