KEGG   ENZYME: 1.1.1.166Help
Entry
EC 1.1.1.166                Enzyme                                 

Name
hydroxycyclohexanecarboxylate dehydrogenase;
dihydroxycyclohexanecarboxylate dehydrogenase;
(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H+ [RN:R05315]
Reaction(KEGG)
Substrate
(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate [CPD:C04687];
NAD+ [CPD:C00003]
Product
(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate [CPD:C04670];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial hydroxy or carbonyl group at C-4, including (-)-quinate and (-)-shikimate.
History
EC 1.1.1.166 created 1976
Reference
1  [PMID:4375976]
  Authors
Whiting GC, Coggins RA.
  Title
A new nicotinamide-adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (minus)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate.
  Journal
Biochem. J. 141 (1974) 35-42.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55467-53-3

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