KEGG   ENZYME: 1.1.1.168Help
Entry
EC 1.1.1.168                Enzyme                                 

Name
2-dehydropantolactone reductase (Re-specific);
2-oxopantoyl lactone reductase;
ketopantoyl lactone reductase;
2-ketopantoyl lactone reductase;
2-dehydropantoyl-lactone reductase (A-specific);
(R)-pantolactone:NADP+ oxidoreductase (A-specific);
2-dehydropantolactone reductase (A-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-pantolactone:NADP+ oxidoreductase (Re-specific)
Reaction(IUBMB)
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ [RN:R03155]
Reaction(KEGG)
Substrate
(R)-pantolactone [CPD:C01012];
NADP+ [CPD:C00006]
Product
2-dehydropantolactone [CPD:C01125];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The yeast enzyme differs from that from Escherichia coli [EC 1.1.1.214 2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.
History
EC 1.1.1.168 created 1976, modified 1986, modified 1999
Reference
1  [PMID:4603075]
  Authors
King HL Jr, Dyar RE, Wilken DR.
  Title
Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase.
  Journal
J. Biol. Chem. 249 (1974) 4689-95.
Reference
2  [PMID:234966]
  Authors
Wilken DR, King HL Jr, Dyar RE.
  Title
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.
  Journal
J. Biol. Chem. 250 (1975) 2311-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37211-75-9

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