KEGG   ENZYME: 1.1.1.178Help
Entry
EC 1.1.1.178                Enzyme                                 
Name
3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxy-butyryl CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ [RN:R04203]
Reaction(KEGG)
Substrate
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA [CPD:C04405];
NAD+ [CPD:C00003]
Product
2-methylacetoacetyl-CoA [CPD:C03344];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
Pathway
Valine, leucine and isoleucine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K08683  
3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Genes
HSA: 
3028(HSD17B10)
PTR: 
465649(HSD17B10)
PPS: 
100971848(HSD17B10)
GGO: 
PON: 
100459385(HSD17B10)
MCC: 
700018(HSD17B10)
MMU: 
15108(Hsd17b10)
RNO: 
63864(Hsd17b10)
CFA: 
480930(HSD17B10)
AML: 
FCA: 
101090672(HSD17B10)
BTA: 
281809(HSD17B10)
SSC: 
100524293
ECB: 
100060335
MDO: 
100019657
SHR: 
100918332(HSD17B10)
OAA: 
100081790
GGA: 
425758(HSD17B10)
MGP: 
100538711 100540780
TGU: 
100228698
ACS: 
100566347
XLA: 
446903(hsd17b10)
XTR: 
549265(hsd17b10)
DRE: 
450078(hsd17b10)
TRU: 
101074613
OLA: 
101170516
BFO: 
BRAFLDRAFT_291364
CIN: 
100180343
SPU: 
579135
DME: 
Dmel_CG7113(scu)
DPO: 
Dpse_GA20113
DAN: 
Dana_GF19368
DER: 
Dere_GG19147
DPE: 
Dper_GL14944
DSE: 
Dsec_GM22877
DSI: 
Dsim_GD17383
DWI: 
Dwil_GK25326
DYA: 
Dyak_GE17707
DGR: 
Dgri_GH24783
DMO: 
Dmoj_GI14682
DVI: 
Dvir_GJ16589
AGA: 
AgaP_AGAP003414
AAG: 
AaeL_AAEL009324
CQU: 
CpipJ_CPIJ014285
AME: 
725274
NVI: 
100114736(NV10288)
TCA: 
660648
API: 
100164493
PHU: 
Phum_PHUM489260
ISC: 
IscW_ISCW018873
CEL: 
CELE_F01G4.2(ard-1)
CBR: 
CBG06017(Cbr-ard-1)
BMY: 
Bm1_06360
SMM: 
Smp_151030
NVE: 
NEMVE_v1g163220
TAD: 
TRIADDRAFT_22420 TRIADDRAFT_51183
AQU: 
100642054
MBR: 
MONBRDRAFT_35161
TPS: 
THAPS_263178(HCD1)
PIF: 
PITG_05542
 » show all
Taxonomy
Reference
1  [PMID:4150713]
  Authors
Conrad RS, Massey LK, Sokatch JR.
  Title
D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida.
  Journal
J. Bacteriol. 118 (1974) 103-11.
  Organism
Pseudomonas putida
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52227-66-4
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