KEGG   ENZYME: 1.1.1.183Help
Entry
EC 1.1.1.183                Enzyme                                 

Name
geraniol dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
geraniol:NADP+ oxidoreductase
Reaction(IUBMB)
geraniol + NADP+ = geranial + NADPH + H+ [RN:R03581]
Reaction(KEGG)
Substrate
geraniol [CPD:C01500];
NADP+ [CPD:C00006]
Product
geranial [CPD:C01499];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly on farnesol but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.
History
EC 1.1.1.183 created 1983
Pathway
Geraniol degradation
Biosynthesis of antibiotics
Reference
1
  Authors
Potty, V.H. and Bruemmer, J.H.
  Title
Oxidation of geraniol by an enzyme system from orange.
  Journal
Phytochemistry 9 (1970) 1001-1007.
Reference
2  [PMID:11743782]
  Authors
Sekiwa-Iijima Y, Aizawa Y, Kubota K
  Title
Geraniol dehydrogenase activity related to aroma formation in ginger (Zingiber officinale Roscoe).
  Journal
J. Agric. Food. Chem. 49 (2001) 5902-6.
Reference
3  [PMID:21636906]
  Authors
Saito Y, Ito S, Koltunow AM, Sakai H
  Title
Crystallization and preliminary X-ray analysis of geraniol dehydrogenase from Backhousia citriodora (lemon myrtle).
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 67 (2011) 665-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
56802-96-1

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