KEGG   ENZYME: 1.1.1.185Help
Entry
EC 1.1.1.185                Enzyme                                 

Name
L-glycol dehydrogenase;
glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase;
L-(+)-glycol:NAD(P)+ oxidoreductase;
L-glycol:NAD(P)+ dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-glycol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+ [RN:R03584 R03585]
Reaction(KEGG)
Substrate
L-glycol [CPD:C01506];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2-hydroxycarbonyl compound [CPD:C03667];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The 2-hydroxycarbonyl compound formed can be further oxidized to a vicinal dicarbonyl compound. In the reverse direction, vicinal diketones, glyceraldehyde, glyoxal, methylglyoxal, 2-oxo-hydroxyketones and 2-ketoacid esters can be reduced.
History
EC 1.1.1.185 created 1984
Reference
1  [PMID:7018582]
  Authors
Bernardo A, Burgos J, Martin R.
  Title
Purification and some properties of L-glycol dehydrogenase from hen's muscle.
  Journal
Biochim. Biophys. Acta. 659 (1981) 189-98.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
77967-75-0

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