KEGG   ENZYME: 1.1.1.19Help
Entry
EC 1.1.1.19                 Enzyme                                 
Name
glucuronate reductase;
aldehyde reductase;
L-hexonate:NADP dehydrogenase;
TPN-L-gulonate dehydrogenase;
aldehyde reductase II;
NADP-L-gulonate dehydrogenase;
D-glucuronate dehydrogenase;
D-glucuronate reductase;
L-glucuronate reductase (incorrect)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-gulonate:NADP+ 6-oxidoreductase
Reaction(IUBMB)
L-gulonate + NADP+ = D-glucuronate + NADPH + H+ [RN:R01481]
Reaction(KEGG)
Substrate
L-gulonate [CPD:C00800];
NADP+ [CPD:C00006]
Product
D-glucuronate [CPD:C00191];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also reduces D-galacturonate. May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)].
Pathway
Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Metabolic pathways
Reference
1  [PMID:13913518]
  Authors
SIVAK A, HOFFMANN-OSTENHOF O.
  Title
Enzymes of mesoinositol catabolism in the yeast Schwanniomyces accidentalis.
  Journal
Biochim. Biophys. Acta. 53 (1961) 426-8.
  Organism
Schwanniomyces occidentalis
Reference
2
  Authors
von Wartburg, J.P. and Wermoth, B.
  Title
Aldehyde reductase.
  Journal
In: Jakoby, W.B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, p. 249-260.
Reference
3  [PMID:13787380]
  Authors
YORK JL, GROLLMAN AP, BUBLITZ C.
  Title
TPN-L-gluonate dehydrogenase.
  Journal
Biochim. Biophys. Acta. 47 (1961) 298-306.
  Organism
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-29-9
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