KEGG   ENZYME: 1.1.1.197Help
Entry
EC 1.1.1.197                Enzyme                                 

Name
15-hydroxyprostaglandin dehydrogenase (NADP+);
NADP-dependent 15-hydroxyprostaglandin dehydrogenase;
NADP-linked 15-hydroxyprostaglandin dehydrogenase;
NADP-specific 15-hydroxyprostaglandin dehydrogenase;
type II 15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase
Reaction(IUBMB)
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+ [RN:R04552]
Reaction(KEGG)
Substrate
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate [CPD:C04741];
NADP+ [CPD:C00006]
Product
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate [CPD:C04654];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.
History
EC 1.1.1.197 created 1984
Orthology
K00079  
carbonyl reductase 1
Genes
HSA: 
873(CBR1)
PTR: 
473983(CBR1)
PPS: 
100984486(CBR1)
GGO: 
101128365(CBR1)
PON: 
100172097(CBR1)
NLE: 
100595150(CBR1)
MCC: 
699655(CBR1)
MCF: 
102141127(CBR1)
CSAB: 
103218526(CBR1)
RRO: 
104680046(CBR1)
RBB: 
108536876(CBR1)
CJC: 
100385429(CBR1)
SBQ: 
101053953(CBR1)
MMU: 
12408(Cbr1)
RNO: 
CGE: 
NGI: 
103736428(Cbr1)
HGL: 
CCAN: 
OCU: 
TUP: 
102493488(CBR1)
CFA: 
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
510180(MGC127133) 515946(CBR1)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
102513911(CBR1)
CDK: 
BACU: 
LVE: 
103084663(CBR1)
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
102773942(CBR1)
HAI: 
RSS: 
PALE: 
102891228(CBR1)
LAV: 
MDO: 
SHR: 
100920969(CBR1)
OAA: 
100081857(CBR1)
GGA: 
418512(CBR1)
MGP: 
100550018(CBR1)
CJO: 
APLA: 
101794661(CBR1)
ACYG: 
TGU: 
100222525(CBR1)
GFR: 
102043656(CBR1)
FAB: 
PHI: 
102114609(CBR1)
CCW: 
FPG: 
101915985(CBR1)
FCH: 
102057061(CBR1)
CLV: 
102094554(CBR1)
AAM: 
ASN: 
102386516(CBR1)
AMJ: 
102575087(CBR1)
PSS: 
102454231(CBR1)
CMY: 
CPIC: 
101937374(CBR1)
ACS: 
PBI: 
103066276(CBR1)
GJA: 
XLA: 
XTR: 
NPR: 
DRE: 
337696(cbr1l) 373866(cbr1)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
101070504(cbr1)
TNG: 
LCO: 
104925597(cbr1)
NCC: 
MZE: 
OLA: 
100125494(cbr1)
XMA: 
CSEM: 
103387805(cbr1)
LCF: 
108872922(cbr1)
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
AME: 
551072(GB16229)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
DPX: 
ISC: 
TUT: 
BMY: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
OVI: 
NVE: 
ADF: 
HMG: 
AQU: 
CRB: 
THJ: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj4g3v0510200.1(Lj4g3v0510200.1)
LANG: 
FVE: 
PPER: 
PMUM: 
PXB: 
ZJU: 
CMO: 
RCU: 
POP: 
SLY: 
SPEN: 
SOT: 
CANN: 
NTA: 
INI: 
SIND: 
NNU: 
BDI: 
PDA: 
EGU: 
SMO: 
PPP: 
CRE: 
CSL: 
GSL: 
TTT: 
MTM: 
VAL: 
VDA: 
CFJ: 
GLZ: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
SHS: 
ADL: 
GTR: 
MRR: 
SCM: 
UMA: 
PFP: 
SRE: 
ACAN: 
SMIN: 
v1.2.027692.t1(symbB.v1.2.027692.t1)
FCY: 
AAF: 
SPAR: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:234431]
  Authors
Lee SC, Levine L.
  Title
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.
  Journal
J. Biol. Chem. 250 (1975) 548-52.
Reference
2  [PMID:803247]
  Authors
Lee SC, Pong SS, Katzen D, Wu KY, Levine L.
  Title
Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
  Journal
Biochemistry. 14 (1975) 142-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
54989-39-8

DBGET integrated database retrieval system