KEGG   ENZYME: 1.1.1.201Help
Entry
EC 1.1.1.201                Enzyme                                 

Name
7beta-hydroxysteroid dehydrogenase (NADP+);
NADP+-dependent 7beta-hydroxysteroid dehydrogenase;
7beta-hydroxysteroid dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
7beta-hydroxysteroid:NADP+ 7-oxidoreductase
Reaction(IUBMB)
a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+ [RN:R03753]
Reaction(KEGG)
Substrate
7beta-hydroxysteroid [CPD:C02956];
NADP+ [CPD:C00006]
Product
7-oxosteroid [CPD:C01881];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the oxidation of the 7beta-hydroxy group of bile acids such as ursodeoxycholate.
History
EC 1.1.1.201 created 1984
Reference
1  [PMID:6954878]
  Authors
Hirano S, Masuda N.
  Title
Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens.
  Journal
Appl. Environ. Microbiol. 43 (1982) 1057-63.
Reference
2  [PMID:6945134]
  Authors
MacDonald IA, Roach PD.
  Title
Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum.
  Journal
Biochim. Biophys. Acta. 665 (1981) 262-9.
Reference
3  [PMID:6758698]
  Authors
MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV.
  Title
Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.
  Journal
Appl. Environ. Microbiol. 44 (1982) 1187-95.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
79393-83-2

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