KEGG   ENZYME: 1.1.1.209Help
Entry
EC 1.1.1.209                Enzyme                                 

Name
3(or 17)alpha-hydroxysteroid dehydrogenase;
3(17)alpha-hydroxysteroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
androsterone + NAD(P)+ = 5alpha-androstane-3,17-dione + NAD(P)H + H+ [RN:R02476 R02477]
Reaction(KEGG)
Substrate
androsterone [CPD:C00523];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
5alpha-androstane-3,17-dione [CPD:C00674];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase).
History
EC 1.1.1.209 created 1986
Reference
1  [PMID:6955302]
  Authors
Lau PC, Layne DS, Williamson DG.
  Title
A 3(17) alpha-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme.
  Journal
J. Biol. Chem. 257 (1982) 9444-9.
Reference
2  [PMID:6955303]
  Authors
Lau PC, Layne DS, Williamson DG.
  Title
Comparison of the multiple forms of the soluble 3(17) alpha-hydroxysteroid dehydrogenases of female rabbit kidney and liver.
  Journal
J. Biol. Chem. 257 (1982) 9450-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83294-77-3

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