KEGG   ENZYME: 1.1.1.210Help
Entry
EC 1.1.1.210                Enzyme                                 

Name
3beta(or 20alpha)-hydroxysteroid dehydrogenase;
progesterone reductase;
dehydrogenase, 3beta,20alpha-hydroxy steroid;
3beta,20alpha-hydroxysteroid oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase
Reaction(IUBMB)
5alpha-androstan-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + NADPH + H+ [RN:R04344]
Reaction(KEGG)
Substrate
5alpha-androstan-3beta,17beta-diol [CPD:C12525];
NADP+ [CPD:C00006]
Product
17beta-hydroxy-5alpha-androstan-3-one [CPD:C03917];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on 20alpha-hydroxysteroids.
History
EC 1.1.1.210 created 1986
Reference
1  [PMID:6958329]
  Authors
Sharaf MA, Sweet F.
  Title
Dual activity at an enzyme active site: 3 beta,20 alpha-hydroxysteroid oxidoreductase from fetal blood.
  Journal
Biochemistry. 21 (1982) 4615-20.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82869-26-9

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