KEGG   ENZYME: 1.1.1.214Help
Entry
EC 1.1.1.214                Enzyme                                 

Name
2-dehydropantolactone reductase (Si-specific);
2-oxopantoyl lactone reductase;
2-ketopantoyl lactone reductase;
ketopantoyl lactone reductase;
2-dehydropantoyl-lactone reductase (B-specific);
(R)-pantolactone:NADP+ oxidoreductase (B-specific);
2-dehydropantolactone reductase (B-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-pantolactone:NADP+ oxidoreductase (Si-specific)
Reaction(IUBMB)
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ [RN:R03155]
Reaction(KEGG)
Substrate
(R)-pantolactone [CPD:C01012];
NADP+ [CPD:C00006]
Product
2-dehydropantolactone [CPD:C01125];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The Escherichia coli enzyme differs from that from yeast [EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific)], which is specific for the Re-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.
History
EC 1.1.1.214 created 1986, modified 1999, modified 2013
Reference
1  [PMID:234966]
  Authors
Wilken DR, King HL Jr, Dyar RE.
  Title
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.
  Journal
J. Biol. Chem. 250 (1975) 2311-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37211-75-9

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