KEGG   ENZYME: 1.1.1.218Help
Entry
EC 1.1.1.218                Enzyme                                 

Name
morphine 6-dehydrogenase;
naloxone reductase;
reductase, naloxone
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
morphine:NAD(P)+ 6-oxidoreductase
Reaction(IUBMB)
morphine + NAD(P)+ = morphinone + NAD(P)H + H+ [RN:R03591 R03592]
Reaction(KEGG)
Substrate
morphine [CPD:C01516];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
morphinone [CPD:C01735];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analogue. Activated by 2-mercaptoethanol.
History
EC 1.1.1.218 created 1989, modified 1990
Pathway
Isoquinoline alkaloid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K03378  
morphine 6-dehydrogenase
K13374  
aldo-keto reductase family 1 member C13
Genes
MMU: 
27384(Akr1c13)
Taxonomy
Reference
1  [PMID:2580834]
  Authors
Yamano S, Kageura E, Ishida T, Toki S.
  Title
Purification and characterization of guinea pig liver morphine 6-dehydrogenase.
  Journal
J. Biol. Chem. 260 (1985) 5259-64.
Reference
2  [PMID:3539118]
  Authors
Yamano S, Nishida F, Toki S.
  Title
Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase.
  Journal
Biochem. Pharmacol. 35 (1986) 4321-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97002-71-6

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