KEGG   ENZYME: 1.1.1.220Help
Entry
EC 1.1.1.220                Enzyme                                 

Name
6-pyruvoyltetrahydropterin 2'-reductase;
6-pyruvoyltetrahydropterin reductase;
6PPH4(2'-oxo) reductase;
6-pyruvoyl tetrahydropterin (2'-oxo)reductase;
6-pyruvoyl-tetrahydropterin 2'-reductase;
pyruvoyl-tetrahydropterin reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase
Reaction(IUBMB)
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ = 6-pyruvoyltetrahydropterin + NADPH + H+ [RN:R04285]
Reaction(KEGG)
Substrate
6-lactoyl-5,6,7,8-tetrahydropterin [CPD:C04244];
NADP+ [CPD:C00006]
Product
6-pyruvoyltetrahydropterin [CPD:C03684];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Not identical with EC 1.1.1.153 sepiapterin reductase.
History
EC 1.1.1.220 created 1989
Pathway
Folate biosynthesis
Metabolic pathways
Orthology
K04071  
6-pyruvoyltetrahydropterin 2'-reductase
Genes
HPY: 
HPA: 
CJE: 
CJJ: 
CJU: 
CJR: 
CJD: 
CFF: 
CCV: 
CHA: 
CLA: 
PTO: 
 » show all
Taxonomy
Reference
1  [PMID:4004850]
  Authors
Milstien S, Kaufman S.
  Title
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates.
  Journal
Biochem. Biophys. Res. Commun. 128 (1985) 1099-107.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97089-79-7

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