KEGG   ENZYME: 1.1.1.225Help
Entry
EC 1.1.1.225                Enzyme                                 

Name
chlordecone reductase;
CDR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
chlordecone-alcohol:NADP+ 2-oxidoreductase
Reaction(IUBMB)
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ [RN:R03716]
Reaction(KEGG)
Substrate
chlordecone alcohol [CPD:C02817];
NADP+ [CPD:C00006]
Product
chlordecone [CPD:C01792];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Chlordecone is an organochlorine pesticide.
History
EC 1.1.1.225 created 1989
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Genes
HSA: 1109(AKR1C4)
PTR: 450274(AKR1C4)
PPS: 100987989
GGO: 101148343(AKR1C4)
NLE: 100605385(AKR1C4)
MCF: 102117205(AKR1C4)
CSAB: 103237814
RBB: 108521035
CJC: 100405255 100405615(AKR1C4)
SBQ: 101041915
Taxonomy
Reference
1  [PMID:2427522]
  Authors
Molowa DT, Shayne AG, Guzelian PS.
  Title
Purification and characterization of chlordecone reductase from human liver.
  Journal
J. Biol. Chem. 261 (1986) 12624-7.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.225
IUBMB Enzyme Nomenclature: 1.1.1.225
ExPASy - ENZYME nomenclature database: 1.1.1.225
BRENDA, the Enzyme Database: 1.1.1.225
CAS: 102484-73-1

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