KEGG   ENZYME: 1.1.1.229Help
Entry
EC 1.1.1.229                Enzyme                                 

Name
diethyl 2-methyl-3-oxosuccinate reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase
Reaction(IUBMB)
diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + NADPH + H+ [RN:R04387]
Reaction(KEGG)
Substrate
diethyl (2R,3R)-2-methyl-3-hydroxysuccinate [CPD:C04586];
NADP+ [CPD:C00006]
Product
diethyl 2-methyl-3-oxosuccinate [CPD:C04067];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on diethyl (2S,3R)-2-methyl-3-hydroxysuccinate; and on the corresponding dimethyl esters.
History
EC 1.1.1.229 created 1990
Reference
1
  Authors
Furuichi, A., Akita, H., Matsukura, H., Oishi, T. and Horikoshi, K.
  Title
Purification and properties of an asymmetric reduction of diethyl 2-methyl-3-oxosuccinate in Saccharomyces fermentati.
  Journal
Agric. Biol. Chem. 51 (1987) 293-299.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
110369-21-6

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