KEGG   ENZYME: 1.1.1.231Help
Entry
EC 1.1.1.231                Enzyme                                 

Name
15-hydroxyprostaglandin-I dehydrogenase (NADP+);
prostacyclin dehydrogenase;
PG I2 dehydrogenase;
prostacyclin dehydrogenase;
NADP+-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase;
NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostaglandin-I dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase
Reaction(IUBMB)
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R03520]
Reaction(KEGG)
Substrate
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [CPD:C01312];
NADP+ [CPD:C00006]
Product
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate [CPD:C04835];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Specific for prostaglandin I2.
History
EC 1.1.1.231 created 1990
Reference
1  [PMID:6182444]
  Authors
Korff JM, Jarabak J.
  Title
Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney.
  Journal
Methods. Enzymol. 86 (1982) 152-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
79468-49-8

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