KEGG   ENZYME: 1.1.1.235Help
Entry
EC 1.1.1.235                Enzyme                                 

Name
8-oxocoformycin reductase;
8-ketodeoxycoformycin reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
coformycin:NADP+ 8-oxidoreductase
Reaction(IUBMB)
coformycin + NADP+ = 8-oxocoformycin + NADPH + H+ [RN:R03667]
Reaction(KEGG)
Substrate
coformycin [CPD:C01677];
NADP+ [CPD:C00006]
Product
8-oxocoformycin [CPD:C02243];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Si-specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin.
History
EC 1.1.1.235 created 1992
Reference
1  [PMID:3052586]
  Authors
Hanvey JC, Hawkins ES, Baker DC, Suhadolnik RJ.
  Title
8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin.
  Journal
Biochemistry. 27 (1988) 5790-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
114995-16-3

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