KEGG   ENZYME: 1.1.1.238Help
Entry
EC 1.1.1.238                Enzyme                                 

Name
12beta-hydroxysteroid dehydrogenase;
12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
12beta-hydroxysteroid:NADP+ 12-oxidoreductase
Reaction(IUBMB)
3alpha,7alpha,12beta-trihydroxy-5beta-cholan-24-oate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate + NADPH + H+ [RN:R03495]
Reaction(KEGG)
Substrate
3alpha,7alpha,12beta-trihydroxy-5beta-cholan-24-oate;
NADP+ [CPD:C00006]
Product
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a number of bile acids, both in their free and conjugated forms.
History
EC 1.1.1.238 created 1992
Reference
1  [PMID:3167086]
  Authors
Edenharder R, Pfutzner A.
  Title
Characterization of NADP-dependent 12 beta-hydroxysteroid dehydrogenase from Clostridium paraputrificum.
  Journal
Biochim. Biophys. Acta. 962 (1988) 362-70.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
118390-62-8

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