KEGG   ENZYME: 1.1.1.248Help
Entry
EC 1.1.1.248                Enzyme                                 

Name
salutaridine reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
salutaridinol:NADP+ 7-oxidoreductase
Reaction(IUBMB)
salutaridinol + NADP+ = salutaridine + NADPH + H+ [RN:R04697]
Reaction(KEGG)
Substrate
salutaridinol [CPD:C05220];
NADP+ [CPD:C00006]
Product
salutaridine [CPD:C05179];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reversible reduction of salutaridine to salutaridinol, which is a direct precursor of morphinan alkaloids in the poppy plant.
History
EC 1.1.1.248 created 1999, modified 2001
Pathway
Isoquinoline alkaloid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K13392  
salutaridine reductase (NADPH)
Reference
1
  Authors
Gerady, R. and Zenk, M.H.
  Title
Purification and characterization of salutaridine:NADPH 7-oxidoreductase from Papaver somniferum.
  Journal
Phytochemistry 34 (1993) 125-132.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
152743-95-8

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