KEGG   ENZYME: 1.1.1.252Help
Entry
EC 1.1.1.252                Enzyme                                 

Name
tetrahydroxynaphthalene reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
scytalone:NADP+ Delta5-oxidoreductase
Reaction(IUBMB)
scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+ [RN:R02906]
Reaction(KEGG)
R02906;
(other) R03322
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Substrate
scytalone [CPD:C00779];
NADP+ [CPD:C00006]
Product
1,3,6,8-tetrahydroxynaphthalene [CPD:C04033];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC 4.2.1.94 scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi.
History
EC 1.1.1.252 created 1992 as EC 1.3.1.50, transferred 1999 to EC 1.1.1.252
Orthology
K17739  tetrahydroxynaphthalene reductase
Genes
NCR: NCU09390(tnr-1)
NTE: NEUTE1DRAFT102704(NEUTE1DRAFT_102704)
SMP: SMAC_05650(tih)
PAN: PODANS72p035 PODANSg1142 PODANSg8553
TTT: THITE_2145571
MTM: MYCTH_2064803 MYCTH_2127410
CTHR: CTHT_0020210 CTHT_0037040
MGR: MGG_02252
TMN: UCRPA7_2613
VAL: VDBG_02748
BFU: BCIN_04g04800(Bcbrn1)
MBE: MBM_00285
 » show all
Taxonomy
Reference
1
  Authors
Wheeler, M.H. and Greenblatt, G.A.
  Title
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
  Journal
Exp. Mycol. 12 (1988) 151-160.
Reference
2  [PMID:8112349]
  Authors
Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M.
  Title
Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing.
  Journal
Eur. J. Biochem. 219 (1994) 985-92.
  Sequence
[mgr:MGG_02252]
Reference
3  [PMID:9048570]
  Authors
Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB.
  Title
Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism.
  Journal
Biochemistry. 36 (1997) 1852-60.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.252
IUBMB Enzyme Nomenclature: 1.1.1.252
ExPASy - ENZYME nomenclature database: 1.1.1.252
BRENDA, the Enzyme Database: 1.1.1.252
CAS: 141350-13-2

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