KEGG   ENZYME: 1.1.1.268Help
Entry
EC 1.1.1.268                Enzyme                                 

Name
2-(R)-hydroxypropyl-CoM dehydrogenase;
2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase
Reaction(IUBMB)
2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+ [RN:R05689]
Reaction(KEGG)
Substrate
2-(R)-hydroxypropyl-CoM [CPD:C11496];
NAD+ [CPD:C00003]
Product
2-oxopropyl-CoM [CPD:C11497];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme is highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, 2-(S)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (S)-enantiomer. This enzyme forms component III of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
History
EC 1.1.1.268 created 2001
Reference
1  [PMID:10411892]
  Authors
Allen JR, Clark DD, Krum JG, Ensign SA.
  Title
A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 8432-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
244301-33-5

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