KEGG   ENZYME: 1.1.1.270Help
Entry
EC 1.1.1.270                Enzyme                                 

Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R05691]
Reaction(KEGG)
R05691;
(other) R04328 R07495
Show
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
Steroid biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Orthology
K09827  
3-keto steroid reductase
K13373  
17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 
51478(HSD17B7)
PTR: 
466046 747814(HSD17B7)
PPS: 
100985156(HSD17B7)
GGO: 
PON: 
100446761(HSD17B7)
NLE: 
100587120(HSD17B7)
MCC: 
720399(HSD17B7)
MCF: 
102127673(HSD17B7)
CSAB: 
103223654(HSD17B7)
RRO: 
104656967(HSD17B7)
CJC: 
100410416(HSD17B7)
SBQ: 
101047238(HSD17B7)
MMU: 
15490(Hsd17b7)
RNO: 
29540(Hsd17b7)
CGE: 
100767580(Hsd17b7)
NGI: 
103746788(Hsd17b7)
HGL: 
101712707(Hsd17b7)
OCU: 
100008778(HSD17B7) 100349261(HSD17B7)
TUP: 
102473205(HSD17B7)
CFA: 
609364(HSD17B7)
AML: 
100477716(HSD17B7)
UMR: 
103658287(HSD17B7)
FCA: 
101083482(HSD17B7)
PTG: 
102968316(HSD17B7)
BTA: 
505212(HSD17B7)
BOM: 
102266348(HSD17B7)
PHD: 
102316552(HSD17B7)
CHX: 
102179058(HSD17B7)
OAS: 
101110013(HSD17B7)
SSC: 
100155418(HSD17B7)
CFR: 
102512546(HSD17B7)
BACU: 
103014331(HSD17B7)
LVE: 
103084050(HSD17B7)
ECB: 
100059061(HSD17B7)
MYB: 
102251181(HSD17B7)
MYD: 
102767046(HSD17B7)
PALE: 
102892079(HSD17B7)
LAV: 
MDO: 
100016071(HSD17B7)
SHR: 
100926227(HSD17B7)
GGA: 
424367(HSD17B7)
MGP: 
100542640(HSD17B7)
CJO: 
107317140(HSD17B7)
APLA: 
101799136(HSD17B7)
TGU: 
100222823(HSD17B7)
GFR: 
102042580(HSD17B7)
FAB: 
101818521(HSD17B7)
PHI: 
102107312(HSD17B7)
CCW: 
104695594(HSD17B7)
FPG: 
101919410(HSD17B7)
FCH: 
102059217(HSD17B7)
CLV: 
102097738(HSD17B7)
AAM: 
106499711(HSD17B7)
ASN: 
102374189(HSD17B7)
AMJ: 
102565865(HSD17B7)
PSS: 
102461698(HSD17B7)
CMY: 
102944731(HSD17B7)
ACS: 
100556465(hsd17b7)
PBI: 
103063132(HSD17B7)
GJA: 
107121042(HSD17B7)
XLA: 
734717(hsd17b7.S)
XTR: 
548963(hsd17b7)
DRE: 
768185(hsd17b7)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102348492(HSD17B7)
CMK: 
103180036(hsd17b7)
BFO: 
CIN: 
SPU: 
SKO: 
HRO: 
LGI: 
CRG: 
TAD: 
AQU: 
SCE: 
YLR100W(ERG27)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: 
NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: 
TPHA_0C01040(TPHA0C01040)
TBL: 
TBLA_0D04010(TBLA0D04010)
TDL: 
TDEL_0F04160(TDEL0F04160)
KAF: 
KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.10750(ERG27) CaO19.3240(ERG27)
CTP: 
COT: 
CDU: 
CD36_26140(ERG27)
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1904154(AO090003001070)
ANG: 
ANI_1_1880184(An04g05000)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
TMS: 
DSQ: 
HIR: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: 
AGABI2DRAFT202140(AGABI2DRAFT_202140)
CPUT: 
SLA: 
WSE: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
 » show all
Taxonomy
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J. Biol. Chem. 243 (1968) 5546-55.
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch. Biochem. Biophys. 211 (1981) 430-8.
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 12655-60.
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol. Endocrinol. 17 (2003) 1715-25.
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
42616-29-5

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