KEGG   ENZYME: 1.1.1.273Help
Entry
EC 1.1.1.273                Enzyme                                 

Name
vellosimine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
10-deoxysarpagine:NADP+ oxidoreductase
Reaction(IUBMB)
10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+ [RN:R05827]
Reaction(KEGG)
Substrate
10-deoxysarpagine [CPD:C11635];
NADP+ [CPD:C00006]
Product
vellosimine [CPD:C11634];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae.
History
EC 1.1.1.273 created 2002
Pathway
Indole alkaloid biosynthesis
Biosynthesis of secondary metabolites
Reference
1
  Authors
Pfitzner, A., Krausch, B. and Stockigt, J.
  Title
Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine.
  Journal
Tetrahedron 40 (1984) 1691-1699.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
86777-26-6

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