KEGG   ENZYME: 1.1.1.274Help
Entry
EC 1.1.1.274                Enzyme                                 

Name
2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming);
2,5-diketo-D-gluconate reductase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-dehydro-D-gluconate:NADP+ 2-oxidoreductase (2-dehydro-D-gluconate-forming)
Reaction(IUBMB)
2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+ [RN:R05823]
Reaction(KEGG)
R05823;
(other) R08878
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Substrate
2-dehydro-D-gluconate [CPD:C06473];
NADP+ [CPD:C00006]
Product
2,5-didehydro-D-gluconate [CPD:C02780];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in the catabolism of 2,5-didehydrogluconate. cf. EC 1.1.1.346, 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).
History
EC 1.1.1.274 created 2002, modified 2013
Reference
1
  Authors
Sonoyama, T., Kageyama, B., Yagi, S. and Mitsushima, K.
  Title
Biochemical aspects of 2-keto-L-gulonate accumulation from 2,5-diketo-D-gluconate by Corynebacterium sp. and its mutants.
  Journal
Agric. Biol. Chem. 51 (1987) 3039-3047.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
95725-95-4

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