KEGG   ENZYME: 1.1.1.277Help
Entry
EC 1.1.1.277                Enzyme                                 

Name
3beta-hydroxy-5beta-steroid dehydrogenase;
3beta-hydroxysteroid 5beta-oxidoreductase;
3beta-hydroxysteroid 5beta-progesterone oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + NADPH + H+ [RN:R06166]
Reaction(KEGG)
Substrate
3beta-hydroxy-5beta-pregnane-20-one [CPD:C11825];
NADP+ [CPD:C00006]
Product
5beta-pregnan-3,20-dione;
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.277 created 2003
Reference
1
  Authors
Stuhlemmer, U. and Kreis, W.
  Title
Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata.
  Journal
Plant Physiol. 34 (1996) 85-91.
Reference
2
  Authors
Seitz, H.U. and Gaertner, D.E.
  Title
Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea.
  Journal
Plant Cell 38 (1994) 337-344.
Reference
3
  Authors
Lindemann, P. and Luckner, M.
  Title
Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata.
  Journal
Phytochemistry 46 (1997) 507-513.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
162731-81-9

DBGET integrated database retrieval system