KEGG   ENZYME: 1.1.1.278Help
Entry
EC 1.1.1.278                Enzyme                                 

Name
3beta-hydroxy-5alpha-steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnan-3,20-dione + NADPH + H+ [RN:R07138]
Reaction(KEGG)
Substrate
3beta-hydroxy-5alpha-pregnane-20-one;
NADP+ [CPD:C00006]
Product
5alpha-pregnan-3,20-dione;
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.278 created 2003
Reference
1
  Authors
Lindemann, P. and Luckner, M.
  Title
Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata.
  Journal
Phytochemistry 46 (1997) 507-513.
Reference
2  [PMID:2291772]
  Authors
Warneck HM, Seitz HU.
  Title
3 beta-hydroxysteroid oxidoreductase in suspension cultures of Digitalis lanata EHRH.
  Journal
Z. Naturforsch. [C]. 45 (1990) 963-72.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
58875-02-8

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