KEGG   ENZYME: 1.1.1.280Help
Entry
EC 1.1.1.280                Enzyme                                 

Name
(S)-3-hydroxyacid-ester dehydrogenase;
3-oxo ester (S)-reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase
Reaction(IUBMB)
ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + NADPH + H+ [RN:R04106]
Reaction(KEGG)
Substrate
ethyl (S)-3-hydroxyhexanoate [CPD:C03865];
NADP+ [CPD:C00006]
Product
ethyl 3-oxohexanoate [CPD:C02975];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on 4-oxo- and 5-oxo-fatty acids and their esters. cf. EC 1.1.1.279 (R)-3-hydroxyacid-ester dehydrogenase.
History
EC 1.1.1.280 created 1990 as EC 1.2.1.56, transferred 2003 to EC 1.1.1.280
Reference
1  [PMID:3280313]
  Authors
Heidlas J, Engel KH, Tressl R.
  Title
Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast.
  Journal
Eur. J. Biochem. 172 (1988) 633-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
114705-03-2

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