KEGG   ENZYME: 1.1.1.281Help
Entry
EC 1.1.1.281                Enzyme                                 

Name
GDP-4-dehydro-6-deoxy-D-mannose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous];
GDP-6-deoxy-D-lyxo-4-hexulose reductase;
Rmd;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming);
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
GDP-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03397 R03399]
Reaction(KEGG)
Substrate
GDP-alpha-D-rhamnose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
History
EC 1.1.1.281 created 2004
Pathway
Fructose and mannose metabolism
Amino sugar and nucleotide sugar metabolism
Orthology
K15856  
GDP-4-dehydro-6-deoxy-D-mannose reductase
Genes
XAL: 
LCP: 
LGU: 
PAE: 
PA5454(rmd)
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PAEB: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
PAEO: 
PALC: 
PPJ: 
PST: 
PSYR: 
PCI: 
PFO: 
PFE: 
PMAN: 
PBA: 
PPUU: 
PDR: 
PCH: 
PCZ: 
PCP: 
PSES: 
PSEM: 
ACX: 
MME: 
REU: 
HHT: 
CFU: 
CARE: 
CPRA: 
MXA: 
MFU: 
MSD: 
MYM: 
CCX: 
SUR: 
MOP: 
MAM: 
RPA: 
RPD: 
RPE: 
RPT: 
RPX: 
NHA: 
BOP: 
AZC: 
MRD: 
MET: 
MOR: 
RVA: 
MSC: 
BSB: 
HNE: 
ZMN: 
ZMI: 
ZMC: 
ZMR: 
ZMP: 
GOX: 
GOH: 
GOY: 
GBE: 
GBH: 
GBC: 
GBS: 
ACR: 
AMV: 
PGV: 
AFE: 
AFR: 
ACU: 
AFI: 
BTF: 
BMH: 
BIF: 
BSJ: 
BON: 
FPN: 
BBE: 
PJD: 
PPY: 
PPM: 
PPO: 
PPOL: 
PPQ: 
PPOY: 
PMS: 
PMQ: 
PMW: 
PTA: 
PLV: 
PSAB: 
PBD: 
PGM: 
POD: 
PAEN: 
PAEF: 
PAEQ: 
PSTE: 
PAEA: 
PAEE: 
PAEH: 
PAEJ: 
PIH: 
PRI: 
PPEO: 
TCO: 
ANX: 
CCL: 
RCH: 
BPB: 
CLE: 
DRU: 
DAI: 
DED: 
DEC: 
SAP: 
MTU: 
Rv0112(gca)
MTV: 
MTC: 
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
Mb0116(gca)
MBB: 
MBT: 
MBM: 
MBK: 
MBX: 
MBZ: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
AFO: 
ABAI: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
HAU: 
TRO: 
STI: 
CAP: 
TTR: 
LIL: 
LA_0235(rfbB)
LIE: 
LIF_A0204(rfbB)
LIC: 
LIS: 
LIL_10203(rfbB1)
LBJ: 
LBL: 
LBI: 
LBF: 
LST: 
FSC: 
GBA: 
TLI: 
AMO: 
SACI: 
CAMU: 
SBE: 
MIB: 
MPI: 
LOKI: 
AGW: 
 » show all
Taxonomy
Reference
1  [PMID:11096116]
  Authors
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P.
  Title
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J. Biol. Chem. 276 (2001) 5577-83.
  Sequence
Reference
2  [PMID:11856318]
  Authors
Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R.
  Title
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose.
  Journal
Eur. J. Biochem. 269 (2002) 593-601.
  Sequence
[pae:PA5454]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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