KEGG   ENZYME: 1.1.1.286Help
Entry
EC 1.1.1.286                Enzyme                                 

Name
isocitrate---homoisocitrate dehydrogenase;
homoisocitrate---isocitrate dehydrogenase;
PH1722
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1) isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709];
(2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
Substrate
isocitrate [CPD:C00311];
NAD+ [CPD:C00003];
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662]
Product
2-oxoglutarate [CPD:C00026];
CO2 [CPD:C00011];
NADH [CPD:C00004];
2-oxoadipate [CPD:C00322];
H+ [CPD:C00080]
Comment
Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.
History
EC 1.1.1.286 created 2005
Pathway
Citrate cycle (TCA cycle)
Lysine biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Orthology
K17753  
isocitrate--homoisocitrate dehydrogenase
Genes
PHO: 
PH1722(PH1722)
PAB: 
PAB0289(leuB-2)
PYN: 
PYS: 
TKO: 
THS: 
Taxonomy
Reference
1  [PMID:15845397]
  Authors
Miyazaki K.
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem. Biophys. Res. Commun. 331 (2005) 341-6.
  Sequence
[pho:PH1722]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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