KEGG   ENZYME: 1.1.1.287Help
Entry
EC 1.1.1.287                Enzyme                                 

Name
D-arabinitol dehydrogenase (NADP+);
NADP+-dependent D-arabitol dehydrogenase;
ARD1p;
D-arabitol dehydrogenase 1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-arabinitol:NADP+ oxidoreductase
Reaction(IUBMB)
(1) D-arabinitol + NADP+ = D-xylulose + NADPH + H+ [RN:R07143];
(2) D-arabinitol + NADP+ = D-ribulose + NADPH + H+ [RN:R07144]
Reaction(KEGG)
Substrate
D-arabinitol [CPD:C01904];
NADP+ [CPD:C00006]
Product
D-xylulose [CPD:C00310];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-ribulose [CPD:C00309]
Comment
The enzyme from the rust fungus Uromyces fabae can use D-arabinitol and D-mannitol as substrates in the forward direction and D-xylulose, D-ribulose and, to a lesser extent, D-fructose as substrates in the reverse direction. This enzyme carries out the reactions of both EC 1.1.1.11, D-arabinitol 4-dehydrogenase and EC 1.1.1.250, D-arabinitol 2-dehydrogenase, but unlike them, uses NADP+ rather than NAD+ as cofactor. D-Arabinitol is capable of quenching reactive oxygen species involved in defense reactions of the host plant.
History
EC 1.1.1.287 created 2005
Pathway
Pentose and glucuronate interconversions
Metabolic pathways
Orthology
K17818  
D-arabinitol dehydrogenase (NADP+)
Genes
MGR: 
TMN: 
NHE: 
MAW: 
MAJ: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1570154(AO090003000888)
ANG: 
ANI_1_452014(An01g03480)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
BCOM: 
NPA: 
TML: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT116829(AGABI1DRAFT_116829) AGABI1DRAFT46050(AGABI1DRAFT_46050)
ABV: 
AGABI2DRAFT145143(AGABI2DRAFT_145143) AGABI2DRAFT194619(AGABI2DRAFT_194619)
CPUT: 
SLA: 
PGR: 
MLR: 
MSM: 
MSG: 
SRC: 
 » show all
Taxonomy
Reference
1  [PMID:15796718]
  Authors
Link T, Lohaus G, Heiser I, Mendgen K, Hahn M, Voegele RT.
  Title
Characterization of a novel NADP(+)-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae.
  Journal
Biochem. J. 389 (2005) 289-95.
  Sequence
[up:Q4R0J7]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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