KEGG   ENZYME: 1.1.1.288Help
Entry
EC 1.1.1.288                Enzyme                                 

Name
xanthoxin dehydrogenase;
xanthoxin oxidase;
ABA2
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
xanthoxin:NAD+ oxidoreductase
Reaction(IUBMB)
xanthoxin + NAD+ = abscisic aldehyde + NADH + H+
Reaction(KEGG)
(other) R06954
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Substrate
xanthoxin [CPD:C13453];
NAD+ [CPD:C00003]
Product
abscisic aldehyde [CPD:C13455];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Requires a molybdenum cofactor for activity. NADP+ cannot replace NAD+ and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate [3]. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14 (abscisic-aldehyde oxidase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase]. Abscisic acid is a sesquiterpenoid plant hormone that is involved in the control of a wide range of essential physiological processes, including seed development, germination and responses to stress [3].
History
EC 1.1.1.288 created 2005
Pathway
Carotenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K09841  
xanthoxin dehydrogenase
Genes
ATH: 
AT1G52340(ABA2)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
102577974(ABA2)
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0091119.1(Lj0g3v0091119.1)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0001s06170g(POPTRDRAFT_547844)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os03t0810800-01(Os03g0810800)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_01g003880(SORBIDRAFT_01g003880)
ZMA: 
100282128(sca1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
 » show all
Taxonomy
Reference
1  [PMID:16666262]
  Authors
Sindhu RK, Walton DC.
  Title
Xanthoxin Metabolism in Cell-free Preparations from Wild Type and Wilty Mutants of Tomato.
  Journal
Plant. Physiol. 88 (1988) 178-182.
Reference
2  [PMID:9159947]
  Authors
Schwartz SH, Leon-Kloosterziel KM, Koornneef M, Zeevaart JA.
  Title
Biochemical characterization of the aba2 and aba3 mutants in Arabidopsis thaliana.
  Journal
Plant. Physiol. 114 (1997) 161-6.
  Sequence
[ath:AT1G52340]
Reference
3  [PMID:12172025]
  Authors
Gonzalez-Guzman M, Apostolova N, Belles JM, Barrero JM, Piqueras P, Ponce MR, Micol JL, Serrano R, Rodriguez PL.
  Title
The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde.
  Journal
Plant. Cell. 14 (2002) 1833-46.
  Sequence
[ath:AT1G52340]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
129204-37-1

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