KEGG   ENZYME: 1.1.1.295Help
Entry
EC 1.1.1.295                Enzyme                                 

Name
momilactone-A synthase;
momilactone A synthase;
OsMAS
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide:NAD(P)+ oxidoreductase
Reaction(IUBMB)
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P)+ = momilactone A + NAD(P)H + H+ [RN:R08916 R08917]
Reaction(KEGG)
Substrate
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide [CPD:C18016];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
momilactone A [CPD:C18015];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The rice phytoalexin momilactone A is a diterpenoid secondary metabolite that is involved in the defense mechanism of the plant. Momilactone A is produced in response to attack by a pathogen through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme, which catalyses the last step in the biosynthesis of momilactone A, can use both NAD+ and NADP+ but activity is higher with NAD+ [1].
History
EC 1.1.1.295 created 2008
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K13070  
momilactone-A synthase
Genes
OSA: 
4335093(OsJ_13988)
Taxonomy
Reference
1  [PMID:12005050]
  Authors
Atawong A, Hasegawa M, Kodama O.
  Title
Biosynthesis of rice phytoalexin: enzymatic conversion of 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide to momilactone A.
  Journal
Biosci. Biotechnol. Biochem. 66 (2002) 566-70.
  Sequence
[osa:4335093]
Reference
2  [PMID:17872948]
  Authors
Shimura K, Okada A, Okada K, Jikumaru Y, Ko KW, Toyomasu T, Sassa T, Hasegawa M, Kodama O, Shibuya N, Koga J, Nojiri H, Yamane H.
  Title
Identification of a biosynthetic gene cluster in rice for momilactones.
  Journal
J. Biol. Chem. 282 (2007) 34013-8.
  Sequence
[osa:4335093]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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