KEGG   ENZYME: 1.1.1.297Help
Entry
EC 1.1.1.297                Enzyme                                 

Name
limonene-1,2-diol dehydrogenase;
NAD+-dependent limonene-1,2-diol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
menth-8-ene-1,2-diol:NAD+ oxidoreductase
Reaction(IUBMB)
menth-8-ene-1,2-diol + NAD+ = 1-hydroxymenth-8-en-2-one + NADH + H+ (general reaction) [RN:R08919];
(1) (1S,2S,4R)-menth-8-ene-1,2-diol + NAD+ = (1S,4R)-1-hydroxymenth-8-en-2-one + NADH + H+ [RN:R06399];
(2) (1R,2R,4S)-menth-8-ene-1,2-diol + NAD+ = (1R,4S)-1-hydroxymenth-8-en-2-one + NADH + H+ [RN:R09388]
Reaction(KEGG)
Substrate
menth-8-ene-1,2-diol [CPD:C18020];
NAD+ [CPD:C00003];
(1S,2S,4R)-menth-8-ene-1,2-diol [CPD:C07276];
(1R,2R,4S)-menth-8-ene-1,2-diol [CPD:C19082]
Product
1-hydroxymenth-8-en-2-one [CPD:C18019];
NADH [CPD:C00004];
H+ [CPD:C00080];
(1S,4R)-1-hydroxymenth-8-en-2-one [CPD:C11937];
(1R,4S)-1-hydroxymenth-8-en-2-one
Comment
While the enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate.
History
EC 1.1.1.297 created 2008
Pathway
Limonene and pinene degradation
Reference
1  [PMID:10224006]
  Authors
van der Werf MJ, Swarts HJ, de Bont JA.
  Title
Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene.
  Journal
Appl. Environ. Microbiol. 65 (1999) 2092-102.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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