KEGG   ENZYME: 1.1.1.302Help
Entry
EC 1.1.1.302                Enzyme                                 

Name
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase;
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase;
MjaRED;
MJ0671 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+ [RN:R09375 R09376]
Reaction(KEGG)
Substrate
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one [CPD:C18910];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC 1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate [1].
History
EC 1.1.1.302 created 2010, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K14654  2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
Genes
CME: CYME_CMQ053C
CCP: CHC_T00006214001
SCE: YBR153W(RIB7)
AGO: AGOS_AER037C
ERC: Ecym_5336
KLA: KLLA0F21120g
KMX: KLMA_40225(RIB7)
LTH: KLTH0G15576g
VPO: Kpol_1053p40
ZRO: ZYRO0B06028g
NCS: NCAS_0I02380(NCAS0I02380)
NDI: NDAI_0A06950(NDAI0A06950)
TPF: TPHA_0A00760(TPHA0A00760)
TBL: TBLA_0F01170(TBLA0F01170)
TDL: TDEL_0D05100(TDEL0D05100)
KAF: KAFR_0G01390(KAFR0G01390)
SPAA: SPAPADRAFT_71929(RIB7)
CAL: CAALFM_C112810WA(CaO19.6341)
CAUR: QG37_00137
SLB: AWJ20_3203(RIB7)
NCR: NCU08313
NTE: NEUTE1DRAFT60176(NEUTE1DRAFT_60176)
MGR: MGG_12162
CMT: CCM_05336
BFU: BCIN_09g06970(Bcrib7)
MBE: MBM_02523
ANI: AN6979.2
ANG: ANI_1_1020124(An14g00090) ANI_1_2310014(An01g01960)
ABE: ARB_06025
TVE: TRV_01178
PTE: PTT_14981
CNB: CNBA6060
ABP: AGABI1DRAFT67276(AGABI1DRAFT_67276)
ABV: AGABI2DRAFT213834(AGABI2DRAFT_213834)
MGL: MGL_2361
RGE: RGE_09730(ribD)
MJA: MJ_0671
MMP: MMP1348
MMD: GYY_07565
MAE: Maeo_0660
MVO: Mvol_0148
MAC: MA_4092(ribD) MA_4367(ribD)
MBU: Mbur_2352
MMH: Mmah_1489
MPY: Mpsy_2065
MTP: Mthe_0604
MCJ: MCON_0173(ribD)
MHI: Mhar_1003
MEMA: MMAB1_0301 MMAB1_1511(ribD)
RCI: LRC156(ribD) RRC489
MTH: MTH_235
MMG: MTBMA_c06840(ribD)
METC: MTCT_0197
METE: tca_00215(ribD2)
MST: Msp_1185
MSI: Msm_0065
MRU: mru_1007(ribD)
MEB: Abm4_0661(ribD)
MMIL: sm9_1007(ribD)
MEYE: TL18_05380
MOL: YLM1_0551
MFC: BRM9_1623(ribD1) BRM9_2175(ribD2)
MFV: Mfer_0597
MKA: MK0098(ribD)
AFU: AF_2007
FPL: Ferp_1264
GAC: GACE_1041
GAH: GAH_01541
HAL: VNG_1256G(ribG)
HSL: OE_2802F(ribG)
HHB: Hhub_2572(ribG)
HALH: HTSR_0741(ribD2)
HHSR: HSR6_0767(ribG)
HSU: HLASF_1655(ribD1)
HSF: HLASA_1642(ribD1)
HMA: rrnAC1131(ribG)
HHI: HAH_1738(ribG)
NPH: NP_2672A(arfC)
NMO: Nmlp_2212(ribG)
HUT: Huta_0543
HTI: HTIA_2649
HMU: Hmuk_2416
HWA: HQ_2510A(arfC)
HWC: Hqrw_2809(arfC)
HVO: HVO_1341(ribG)
HME: HFX_1418(ribG)
HLA: Hlac_0451
HTU: Htur_5200
NMG: Nmag_3078
NAT: NJ7G_1457
SALI: L593_07135
FAI: FAD_1195
CDIV: CPM_0367
MEAR: Mpt1_c11210(arfC)
MARC: AR505_1602
ABI: Aboo_0416
ACJ: ACAM_0812
SMR: Smar_0461
IHO: Igni_0956
IIS: EYM_00140
HBU: Hbut_0557
SSO: SSO2097(ribD)
SOL: Ssol_2812
SSOA: SULA_2833
SSOL: SULB_2834
SSOF: SULC_2831
STO: STK_02850
SAI: Saci_2164(rib7)
SID: M164_0517
SII: LD85_0432
SIH: SiH_0852
SIR: SiRe_0492
SIC: SiL_0521
MSE: Msed_0021
MCN: Mcup_0021
AHO: Ahos_0760
PAI: PAE2985
PIS: Pisl_0385
PCL: Pcal_1122
PAS: Pars_1352
PYR: P186_1547
POG: Pogu_0862
TNE: Tneu_1742
CMA: Cmaq_1962
TUZ: TUZN_0676
TTN: TTX_1010(ribD)
VDI: Vdis_2227
VMO: VMUT_0666
ASC: ASAC_1153
NMR: Nmar_1612
NID: NPIRD3C_0441(ribD)
NCT: NMSP_1553(arfC)
NGA: Ngar_c32620(ribD)
NVN: NVIE_021910(ribD)
NEV: NTE_03545
TAA: NMY3_03743(ribD2)
NCV: NCAV_0047
NBV: T478_1325
NDV: NDEV_1966(arfC)
 » show all
Taxonomy
Reference
1  [PMID:11889103]
  Authors
Graupner M, Xu H, White RH
  Title
The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin.
  Journal
J. Bacteriol. 184 (2002) 1952-7.
  Sequence
[mja:MJ_0671]
Reference
2  [PMID:16730025]
  Authors
Chatwell L, Krojer T, Fidler A, Romisch W, Eisenreich W, Bacher A, Huber R, Fischer M
  Title
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.
  Journal
J. Mol. Biol. 359 (2006) 1334-51.
  Sequence
[mja:MJ_0671]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.302
IUBMB Enzyme Nomenclature: 1.1.1.302
ExPASy - ENZYME nomenclature database: 1.1.1.302
BRENDA, the Enzyme Database: 1.1.1.302

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