KEGG   ENZYME: 1.1.1.304Help
Entry
EC 1.1.1.304                Enzyme                                 

Name
diacetyl reductase [(S)-acetoin forming];
(S)-acetoin dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-acetoin:NAD+ oxidoreductase
Reaction(IUBMB)
(S)-acetoin + NAD+ = diacetyl + NADH + H+ [RN:R09078]
Reaction(KEGG)
Substrate
(S)-acetoin [CPD:C01769];
NAD+ [CPD:C00003]
Product
diacetyl [CPD:C00741];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae [1-3]. Different from EC 1.1.1.303, diacetyl reductase [(R)-acetoin forming].
History
EC 1.1.1.304 created 2010 (EC 1.1.1.5 created 1961, modified 1976, part incorporated 2010)
Pathway
ec00650  Butanoate metabolism
Orthology
K03366  meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase
K18009  meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase
Genes
PHD: 102334760
ECY: ECSE_P3-0048
EUN: UMNK88_pK8827
ENT: Ent638_2028
ENC: ECL_03125
ENO: ECENHK_05930
ECLO: ENC_21670
EEC: EcWSU1_01150(budC)
ENL: A3UG_05870
ECLG: EC036_11370
ECLX: LI66_05535
ECLY: LI62_06440
ECLZ: LI64_06070
ENF: AKI40_0780(budC)
CSK: ES15_1123(butA) ES15_2024
CTU: CTU_21210 CTU_29850(budC)
KPN: KPN_02061
KPU: KP1_3140
KPP: A79E_2190
KPT: VK055_0406(budC)
KPE: KPK_2269(budC)
KPR: KPR_3097(budC)
KPJ: N559_2227
KPX: PMK1_04423(budC)
KPNU: LI86_11065
KPNK: BN49_3168(budC)
KVA: Kvar_2212
EAE: EAE_17490
EAR: CCG30393
PSTS: E05_23120(yxbG)
YRU: BD65_651
SPE: Spro_2063
SRL: SOD_c18750(yxbG) SOD_c30770(butA)
SPLY: Q5A_010375(cpnA) Q5A_016695(budC)
SMAF: D781_1887
SMAR: SM39_1526
SERF: L085_18355
RAA: Q7S_23296
ECA: ECA0310(budC)
PATR: EV46_01685
PATO: GZ59_03420(budC)
PCT: PC1_0296
PEC: W5S_0317
SOD: Sant_3892
DDQ: DDI_3151
PAM: PANA_1749(yxbG) PANA_3970(budC)
PAJ: PAJ_1094(yxbG) PAJ_p0039(budC)
PSTW: DSJ_13200
PMR: PMI2092(budC)
PMIB: BB2000_2165(budC)
XBO: XBJ1_2718
XBV: XBW1_2585
XDO: XDD1_2324 XDD1_3345(butA)
XPO: XPG1_1944(xecD)
PSI: S70_03990
PSX: DR96_3957
PRG: RB151_030690(budC)
MMK: MU9_3089
VCH: VC1591
VCE: Vch1786_I1088(alsO)
VCR: VC395_1707(alsO)
VCM: VCM66_1531(alsO)
VCI: O3Y_07715
VCS: MS6_1373
VAG: N646_4032
VAN: VAA_01317
VAU: VANGNB10_cII0928(alsO)
PAE: PA4148
PAEV: N297_4280
PAEI: N296_4280
PAEP: PA1S_04080
PAEM: U769_04105
PAEL: T223_04015
PAEG: AI22_29535
PAEC: M802_4278
PAEO: M801_4146
PPX: T1E_5540 T1E_5544(budC)
PSB: Psyr_0904
PSYR: N018_21135
PPRC: PFLCHA0_c22470(fabG7)
PPRO: PPC_2226
PFC: PflA506_2313(budC)
PFW: PF1751_v1c22140(budC)
PFB: VO64_0806
ACX: Achr_8770
PAR: Psyc_2092
PALI: A3K91_2664
PSYA: AOT82_1902
ACB: A1S_1704
ABM: ABSDF1933(budC)
ABY: ABAYE1944(budC)
ABN: AB57_1932
ABX: ABK1_2198
ABH: M3Q_2090
ABAD: ABD1_16960(budC)
ABAZ: P795_8710
ABAU: IX87_19410
ABAA: IX88_10475
ACC: BDGL_001065(budC)
ACI: ACIAD1022(budC)
ASJ: AsACE_p100042(budC)
MCT: MCR_1660
MCS: DR90_298(budC)
MCAT: MC25239_01577(butA)
SFR: Sfri_0232
ILO: IL0792
PIN: Ping_2541
NOC: Noc_0093
NWA: Nwat_2599
HAM: HALO2446
HBE: BEI_0312(butA)
ADI: B5T_01162
AXE: P40_05520
ECOR: SAMEA4412678_1370(budC)
CNC: CNE_BB1p10260(fabG14)
BTD: BTI_1700
BOK: DM82_1520
BOC: BG90_3190
BVE: AK36_2077
BCN: Bcen_6239
BCJ: BCAL1912(budC)
BCEN: DM39_1802
BCEO: I35_1831(budC)
BMU: Bmul_1433
BMK: DM80_3187
BMUL: NP80_1900
BCED: DM42_3260
BDL: AK34_1284
BCON: NL30_13630
BSEM: WJ12_09225
BPSL: WS57_27515
BMEC: WJ16_09430
BUL: BW21_1792
TAS: TASI_0817
TAT: KUM_0033
BPSI: IX83_03945
ODI: ODI_R3186
AAV: Aave_1551
AAA: Acav_1589
CTES: O987_28195
RTA: Rta_20970
OFO: BRW83_1378(tsaC1)
PCA: Pcar_0903(budY) Pcar_2068(budZ)
PPD: Ppro_3110
SME: SMa0329
SMER: DU99_18895
SMD: Smed_3132
SFD: USDA257_c14870(fabG2) USDA257_c18680(budC)
SAME: SAMCFNEI73_pC1942(budC)
ATU: Atu1905
ARA: Arad_8177
RLE: RL2725
RLG: Rleg_2261
SHZ: shn_27055
BJA: bll5898
RPA: RPA0109
RPT: Rpal_0113
XAU: Xaut_4042
AZC: AZC_1906
MEX: Mext_1326
MDI: METDI1970
MCH: Mchl_1526
MPO: Mpop_0321
BID: Bind_0358
MMED: Mame_00462(pldh-t_2)
HDI: HDIA_0852(budC_1)
RBM: TEF_11220
DSH: Dshi_4158
KRO: BVG79_00066(butA)
LVS: LOKVESSMR4R_03261(polS)
HNE: HNE_0924
HBA: Hbal_1494
ZMO: ZMO0318
ZMN: Za10_0913
ZMM: Zmob_0867
ZMB: ZZ6_0921
ZMI: ZCP4_0946
ZMC: A265_00937(cpnA)
ZMR: A254_00937(cpnA)
SGI: SGRAN_1184(yxbG)
SPHM: G432_13420
SPHI: TS85_23075
SSAN: NX02_p1300
ELI: ELI_09045
GOX: GOX2036
GDI: GDI2623(budA)
GDJ: Gdia_0838
GXL: H845_1119
ASZ: ASN_1243
ALI: AZOLI_0733(budC)
ABS: AZOBR_50037(budC)
TMO: TMO_c0854(budC)
BST: GYO_2246
BLI: BL01177
BLD: BLi02066(budC)
BCL: ABC0681
BAG: Bcoa_1663
BKW: BkAM31D_10020(budC)
VPN: A21D_01009(budC)
SAU: SA0122(butA)
SAV: SAV0126(butA)
SAW: SAHV_0125(butA)
SAM: MW0100(butA)
SAS: SAS0101
SAR: SAR0129
SAC: SACOL0111
SAE: NWMN_0071
SAD: SAAV_0094
SUE: SAOV_0074
SUJ: SAA6159_00110(butA)
SUK: SAA6008_00105(butA)
SUC: ECTR2_82
SUZ: MS7_0118(budC)
SUG: SAPIG0140
SAUA: SAAG_00610
SAUE: RSAU_000081(butA)
SAUS: SA40_0094
SAUU: SA957_0109
SAUG: SA268_0106
SAUV: SAI7S6_1000820(butA)
SAUW: SAI5S5_1000820(butA)
SAUX: SAI6T6_1000820(butA)
SAUY: SAI8T7_1000820(butA)
SAB: SAB0066
SUY: SA2981_0127(butA)
SAUB: C248_0116
SAUM: BN843_1290
SAUC: CA347_139
SAUR: SABB_01714(butA)
SAUI: AZ30_00660
SAUD: CH52_05090
SAUF: X998_0106
SAMS: NI36_00560
SCA: SCA_0065
SXO: SXYL_01072(butA)
SCAP: AYP1020_1850(butA)
MCAK: MCCS_05200(budC)
PSAB: PSAB_18340
LLA: L118271(butA)
LLK: LLKF_0925(butA)
LLT: CVCAS_0859(butA)
LLS: lilo_0848(butA)
LLX: NCDO2118_0917(butA)
LLM: llmg_0339(dar) llmg_1641(butA)
LLI: uc509_0335(dar) uc509_0937(butA)
LLJ: LG36_1428(butA)
LPK: LACPI_0294(budC) LACPI_2399(butA)
SPS: SPs1397
SPF: SpyM51329
STZ: SPYALAB49_000566(budC)
SPYA: A20_0576(budC) A20_0577(budC)
SPYH: L897_02865
SAG: SAG0523
SAN: gbs0569
SAK: SAK_0674
SGC: A964_0556(butA)
SAGM: BSA_6110
SAGI: MSA_6260
SAGR: SAIL_6420
SAGP: V193_02905
SAGC: DN94_02905
SAGE: EN72_03000
SAGG: EN73_03075
SAGN: W903_0700
SMU: SMU_1322(budC)
SMC: SmuNN2025_0740(budC)
SMJ: SMULJ23_0734(budC)
SMUA: SMUFR_1156
SGO: SGO_1096(butA)
SGG: SGGBAA2069_c04210(butA)
SGT: SGGB_0459(butA)
SMB: smi_0567
STK: STP_0088
STB: SGPB_0386(butA)
SCF: Spaf_0915
STJ: SALIVA_1174(butA)
SMN: SMA_0449(butA)
SIF: Sinf_0395
SLU: KE3_0471
LSA: LCA_0292(budC)
LRE: Lreu_1449
LRF: LAR_1360
LHV: lhe_0320
LHD: HUO_10620
LFE: LAF_1480
LFR: LC40_0950
LFF: LBFF_1625
LBN: LBUCD034_0468(butA) LBUCD034_2461(dar)
LSN: LSA_01410(budC)
PPE: PEPE_0286
LGS: LEGAS_0209(butA1) LEGAS_1299(butA2)
WKO: WKK_02035
CPAT: CLPA_c06790(butA) CLPA_c30100(bacC)
CPAE: CPAST_c06790(butA) CPAST_c30100(bacC)
APAL: BN85406040(budC) BN85406050
MVA: Mvan_0789
MGI: Mflv_0124
MVQ: MYVA_0620
MMC: Mmcs_0625
MKM: Mkms_0638
MJL: Mjls_0618
ASD: AS9A_4226
CGL: NCgl2582(Cgl2674)
CGB: cg2958(butA)
CGU: WA5_2582(ButA)
CGT: cgR_2577
CGM: cgp_2958(butA)
CGJ: AR0_12965
CDX: CDES_12115(budC)
CSP: WM42_1088
CGV: CGLAU_02765(budC)
NFA: NFA_30760
NFR: ERS450000_00989(budC_3)
NNO: NONO_c27170(bacC)
RER: RER_06590
RHB: NY08_4367
RFA: A3L23_02474(budC_1)
RHS: A3Q41_00892(budC_2)
RHU: A3Q40_01822(budC_1) A3Q40_02924(fabG_9)
SCO: SCO0256(SCF20.02)
SCT: SCAT_p0291(xecE)
SALU: DC74_7025
SALL: SAZ_36450
STRE: GZL_01568
SMAL: SMALA_7871
SLX: SLAV_34795(fabG19)
CMC: CMN_00047
ARR: ARUE_c08290(xecD)
ARX: ARZXY2_156(butA)
AAU: AAur_0876
NML: Namu_1091
MMAR: MODMU_1341
AMN: RAM_28110
AMM: AMES_5449
AMZ: B737_5449
PSEH: XF36_14320
ACTN: L083_6240
AFS: AFR_03185
BLA: BLA_1253(butA)
BBB: BIF_02081
BBC: BLC1_0697
BLV: BalV_0704
BLW: W7Y_0730
BLS: W91_0752
BANI: Bl12_0681
BANL: BLAC_03715
BANM: EN10_03690
BCOR: BCOR_1070
BSCA: BBSC_0348
LIS: LIL_12284
GAU: GAU_0247
SALI: L593_06440
 » show all
Taxonomy
Reference
1  [PMID:8879540]
  Authors
Giovannini PP, Medici A, Bergamini CM, Rippa M
  Title
Properties of diacetyl (acetoin) reductase from Bacillus stearothermophilus.
  Journal
Bioorg. Med. Chem. 4 (1996) 1197-201.
Reference
2  [PMID:2040298]
  Authors
Carballo J, Martin R, Bernardo A, Gonzalez J
  Title
Purification, characterization and some properties of diacetyl(acetoin) reductase from Enterobacter aerogenes.
  Journal
Eur. J. Biochem. 198 (1991) 327-32.
Reference
3
  Authors
Ui, S., Okajima, Y., Mimura, A., Kanai, H., Kobayashi, T., Kudo, T.
  Title
Sequence analysis of the gene for and characterization of D-acetoin forming meso-2,3-butanediol dehydrogenase of Klebsiella pneumoniae expressed in Escherichia coli.
  Journal
J. Ferment. Bioeng. 83 (1997) 32-37.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.304
IUBMB Enzyme Nomenclature: 1.1.1.304
ExPASy - ENZYME nomenclature database: 1.1.1.304
BRENDA, the Enzyme Database: 1.1.1.304

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