| Entry |
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| Name |
UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating);
UDP-GlcUA decarboxylase;
ArnADH
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
UDP-glucuronate:NAD+ oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+ [RN: R07658]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).
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| Pathway |
| Amino sugar and nucleotide sugar metabolism | | Biosynthesis of secondary metabolites |
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| Orthology |
| UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | EBT: | | STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | PLU: | | PAY: | | WBR: | | WGL: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PMR: | | EIC: | | ETR: | | ETD: | | ETC: | | HDE: | | DDA: | | DDC: | | DDD: | | DZE: | | XBO: | | XNE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | PSI: | | MMK: | | ROR: | | SECT: | | SEHC: | | EBF: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFC: | | PPZ: | | PDR: | | SSE: | | AHA: | | ASA: | | BBH: | | CCO: | | DAO: | |
» show all
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| Reference |
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| Authors |
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR. |
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| Title |
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. |
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| Journal |
J. Biol. Chem. 280 (2005) 14154-67. |
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| Reference |
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| Authors |
Gatzeva-Topalova PZ, May AP, Sousa MC |
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| Title |
Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. |
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| Journal |
Biochemistry. 43 (2004) 13370-9. |
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| Reference |
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| Authors |
Williams GJ, Breazeale SD, Raetz CR, Naismith JH. |
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| Title |
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. |
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| Journal |
J. Biol. Chem. 280 (2005) 23000-8. |
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| Reference |
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| Authors |
Gatzeva-Topalova PZ, May AP, Sousa MC |
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| Title |
Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance. |
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| Journal |
Structure. 13 (2005) 929-42. |
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| Reference |
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| Authors |
Yan A, Guan Z, Raetz CR |
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| Title |
An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. |
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| Journal |
J. Biol. Chem. 282 (2007) 36077-89. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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