KEGG   ENZYME: 1.1.1.306Help
Entry
EC 1.1.1.306                Enzyme                                 

Name
S-(hydroxymethyl)mycothiol dehydrogenase;
NAD/factor-dependent formaldehyde dehydrogenase;
mycothiol-dependent formaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
S-(hydroxymethyl)mycothiol:NAD+ oxidoreductase
Reaction(IUBMB)
S-(hydroxymethyl)mycothiol + NAD+ = S-formylmycothiol + NADH + H+ [RN:R09129]
Reaction(KEGG)
R09129;
(other) R10301
Show
Substrate
S-(hydroxymethyl)mycothiol [CPD:C18235];
NAD+ [CPD:C00003]
Product
S-formylmycothiol [CPD:C06718];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
S-hydroxymethylmycothiol is believed to form spontaneously from formaldehyde and mycothiol. This enzyme oxidizes the product of this spontaneous reaction to S-formylmycothiol, in a reaction that is analogous to EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase.
History
EC 1.1.1.306 created 2010 as EC 1.2.1.66, transferred 2010 to EC 1.1.1.306
Orthology
K00153  
S-(hydroxymethyl)mycothiol dehydrogenase
Genes
RED: 
MALG: 
MTU: 
Rv2259(mscR)
MTV: 
MTC: 
MRA: 
MRA_2280(adhE2)
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
CFBS_2392(adhE2)
MTL: 
MTO: 
MTD: 
UDA_2259(adhE2)
MTN: 
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUL: 
MTUT: 
HKBT1_2383(adhE2)
MTUU: 
HKBT2_2385(adhE2)
MTQ: 
HKBS1_2389(adhE2)
MBO: 
Mb2283(adhE2)
MBB: 
BCG_2277(adhE2)
MBT: 
JTY_2271(adhE2)
MBM: 
MBK: 
MBX: 
MBZ: 
MAF: 
MAF_22700(adhE2)
MCE: 
MCAN_22841(adhE2)
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
MLE: 
ML1784(adhE2)
MLB: 
MLBr01784(adhE2)
MPA: 
MAP_2008(adhE2)
MAO: 
MAVI: 
MAVU: 
MAVD: 
MAVR: 
MAVA: 
MIT: 
MIR: 
MIA: 
MIE: 
MID: 
MYO: 
MSM: 
MSG: 
MSMEI_4240(adhE2)
MSB: 
MSN: 
MSH: 
MSA: 
MUL: 
MUL_1292(adhE2)
MVA: 
MGI: 
MSP: 
MAB: 
MABB: 
MMV: 
MAY: 
MABO: 
MABL: 
MAZ: 
MAK: 
MYS: 
MYC: 
MMC: 
MKM: 
MJL: 
MJD: 
MMI: 
MMAR_3350(adhE2)
MRH: 
MMM: 
MCB: 
MLI: 
MULP_03613(adhE2)
MKN: 
MKS: 
MKI: 
MNE: 
MYV: 
MYE: 
MGO: 
MFT: 
MHAD: 
MPHL: 
MVQ: 
ASD: 
CGL: 
NCgl0313(Cgl0319)
CGB: 
cg0387(adhE)
CGU: 
CGT: 
CGS: 
CGG: 
CGM: 
CGJ: 
CGQ: 
CGX: 
CEF: 
CJK: 
CUR: 
cu1315(mscR)
CUA: 
CAR: 
CKP: 
CRD: 
CVA: 
CHN: 
CCN: 
CTER: 
CMD: 
CFN: 
CCG: 
CVT: 
CGY: 
CAX: 
CII: 
CUV: 
COA: 
CDO: 
CSX: 
CMQ: 
CCJ: 
CEI: 
CTED: 
CUT: 
CLW: 
CDX: 
CSP: 
NFA: 
NCY: 
NBR: 
NNO: 
RHA: 
RER: 
RER_54700(adhC)
REY: 
REB: 
ROP: 
ROP_23120(adhC)
ROA: 
REQ: 
REQ_39460(mscR)
RPY: 
RHB: 
RAV: 
RFA: 
GBR: 
GPO: 
GOR: 
GOQ: 
TPR: 
SRT: 
SCO: 
SCO0741(3SC5B7.19c)
SMA: 
SAV_6953(adhA10)
SGR: 
SGB: 
SCB: 
SSX: 
SVL: 
SCT: 
SCAT_0660(frmA)
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
SALS: 
STRP: 
F750_1483(mscR)
SFI: 
SRC: 
SALU: 
SALL: 
SLV: 
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
SXI: 
STRM: 
STRC: 
SAMB: 
SPRI: 
SCZ: 
SCX: 
SRW: 
STRF: 
KSK: 
ART: 
ARR: 
ARM: 
ARL: 
ARE: 
AAQ: 
ARH: 
ARY: 
ARW: 
AAU: 
AAur_2317(adhE2)
ACH: 
APN: 
PSUL: 
AAI: 
GAR: 
RSA: 
KRH: 
KPL: 
KFV: 
MLU: 
RMU: 
RDN: 
SATK: 
BFA: 
KSE: 
DNI: 
LMOI: 
SKE: 
ARS: 
BLY: 
PPC: 
MPH: 
NCA: 
KFL: 
PSIM: 
AER: 
NDA: 
NAL: 
TCU: 
SRO: 
FRA: 
FRE: 
FRI: 
FAL: 
FSY: 
NML: 
GOB: 
BSD: 
MMAR: 
KRA: 
SEN: 
SVI: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
AMQ: 
ALU: 
PDX: 
PSEA: 
PSEE: 
PSEH: 
PSEQ: 
PECQ: 
AMI: 
SESP: 
KAL: 
KPHY: 
MAU: 
MIL: 
VMA: 
AMS: 
ASE: 
ACPL_1152(adhC)
ACTN: 
AFS: 
CAI: 
SNA: 
MCU: 
AYM: 
CCZ: 
FGI: 
 » show all
Taxonomy
Reference
1  [PMID:9202149]
  Authors
Misset-Smits M, van Ophem PW, Sakuda S, Duine JA.
  Title
Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase.
  Journal
FEBS. Lett. 409 (1997) 221-2.
Reference
2  [PMID:9346279]
  Authors
Norin A, Van Ophem PW, Piersma SR, Persson B, Duine JA, Jornvall H.
  Title
Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases--primary structure, conformational modelling and functional correlations.
  Journal
Eur. J. Biochem. 248 (1997) 282-9.
  Sequence
Reference
3  [PMID:12809551]
  Authors
Vogt RN, Steenkamp DJ, Zheng R, Blanchard JS.
  Title
The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase.
  Journal
Biochem. J. 374 (2003) 657-66.
  Sequence
[mtu:Rv2259]
Reference
4  [PMID:17286835]
  Authors
Rawat M, Av-Gay Y
  Title
Mycothiol-dependent proteins in actinomycetes.
  Journal
FEMS. Microbiol. Rev. 31 (2007) 278-92.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
192140-85-5

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