KEGG   ENZYME: 1.1.1.306Help
Entry
EC 1.1.1.306                Enzyme                                 
Name
S-(hydroxymethyl)mycothiol dehydrogenase;
NAD/factor-dependent formaldehyde dehydrogenase;
mycothiol-dependent formaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
S-(hydroxymethyl)mycothiol:NAD+ oxidoreductase
Reaction(IUBMB)
S-(hydroxymethyl)mycothiol + NAD+ = S-formylmycothiol + NADH + H+ [RN:R09129]
Reaction(KEGG)
Substrate
S-(hydroxymethyl)mycothiol [CPD:C18235];
NAD+ [CPD:C00003]
Product
S-formylmycothiol [CPD:C06718];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
S-hydroxymethylmycothiol is believed to form spontaneously from formaldehyde and mycothiol. This enzyme oxidizes the product of this spontaneous reaction to S-formylmycothiol, in a reaction that is analogous to EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase.
Orthology
K00153  
S-(hydroxymethyl)mycothiol dehydrogenase
Genes
MTU: 
Rv2259(mscR)
MTV: 
MTC: 
MRA: 
MRA_2280(adhE2)
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
CCDC5079_2096
MTL: 
CCDC5180_2068
MTO: 
MTCTRI2_2295(adhE2)
MTD: 
UDA_2259(adhE2)
MTN: 
ERDMAN_2484(adhE2)
MTJ: 
J112_12125
MTUB: 
MT7199_2291(mscR)
MBO: 
Mb2283(adhE2)
MBB: 
BCG_2277(adhE2)
MBT: 
JTY_2271(adhE2)
MBM: 
BCGMEX_2265(adhE2)
MBK: 
K60_023440
MAF: 
MAF_22700(adhE2)
MCE: 
MCAN_22841(adhE2)
MCQ: 
BN44_50206(mscR)
MCV: 
BN43_31502(mscR)
MCX: 
BN42_40181(mscR)
MCZ: 
BN45_50590(mscR)
MLE: 
ML1784(adhE2)
MLB: 
MLBr_01784(adhE2)
MPA: 
MAP2008(adhE2)
MIT: 
OCO_21650
MIR: 
OCQ_20750
MIA: 
OCU_21830
MID: 
MIP_03062
MSM: 
MSMEG_4340
MSG: 
MSMEI_4240(adhE2)
MSA: 
Mycsm_03758 Mycsm_03994 Mycsm_06630
MUL: 
MUL_1292(adhE2)
MVA: 
Mvan_3767
MGI: 
Mflv_2766
MSP: 
Mspyr1_22060
MAB: 
MAB_1869c
MMV: 
MYCMA_0966
MMC: 
Mmcs_3380
MKM: 
Mkms_3442
MJL: 
Mjls_3391
MJD: 
JDM601_1636(adhE2)
MMI: 
MMAR_3350(adhE2)
MRH: 
MycrhN_4422
MMM: 
W7S_10175
MCB: 
Mycch_3288
MLI: 
MULP_03613(adhE2)
ASD: 
AS9A_2336
CGL: 
NCgl0313(Cgl0319)
CGB: 
cg0387(adhE)
CGU: 
WA5_0313
CGT: 
cgR_0403
CEF: 
CE0330
CJK: 
jk0636
CUR: 
cur_1315(mscR)
CUA: 
CU7111_1296(mscR)
CAR: 
cauri_0242(mscR)
CKP: 
ckrop_1021
CRD: 
CRES_0702
CHN: 
A605_01825
CCN: 
H924_01360
NFA: 
nfa12230
NCY: 
NOCYR_4400
NBR: 
O3I_018380 O3I_031325
RHA: 
RHA1_ro02587
RER: 
RER_54700(adhC)
ROP: 
ROP_23120(adhC)
REQ: 
REQ_39460(mscR)
GBR: 
Gbro_0092
GPO: 
GPOL_c02660
GOR: 
KTR9_0076
TPR: 
Tpau_0408
SRT: 
Srot_0127 Srot_2472
SCO: 
SCO0741(3SC5B7.19c)
SMA: 
SAV_6953(adhA10)
SGR: 
SGR_5824
SCB: 
SCAB_7101(adhC) SCAB_8471
SSX: 
SACTE_1114
SVL: 
Strvi_4592 Strvi_5719 Strvi_8775
SCT: 
SCAT_0660(frmA)
SCY: 
SCATT_06690
SFA: 
Sfla_5154
SBH: 
SBI_04973
SHY: 
SHJG_2827 SHJG_8160
SHO: 
SHJGH_2591 SHJGH_7922
SVE: 
SVEN_1275
SDV: 
BN159_0993 BN159_7393
SALB: 
XNR_5600
STRP: 
F750_1483(mscR)
KSK: 
KSE_06610
ART: 
Arth_3723
AAU: 
AAur_2317(adhE2)
ACH: 
Achl_3472
AAI: 
AARI_17700
APN: 
Asphe3_02340
ARR: 
ARUE_c24720
RSA: 
RSal33209_2222
KRH: 
KRH_10130
MLU: 
Mlut_10580
RMU: 
RMDY18_07420
RDN: 
HMPREF0733_12209
BFA: 
Bfae_21860
KSE: 
Ksed_03740
SKE: 
Sked_15330
PPC: 
HMPREF9154_1148
MPH: 
MLP_03010
NCA: 
Noca_3651
KFL: 
Kfla_2454
NDA: 
Ndas_2396
NAL: 
B005_4263
TCU: 
Tcur_2454
SRO: 
Sros_1329
FRA: 
Francci3_1449
FRE: 
Franean1_2925 Franean1_5066
FRI: 
FraEuI1c_2779 FraEuI1c_3788
FAL: 
FRAAL2245
FSY: 
FsymDg_1787
NML: 
Namu_1341
GOB: 
Gobs_4761
BSD: 
BLASA_4642
MMAR: 
MODMU_5128
KRA: 
Krad_0910
SEN: 
SACE_3147 SACE_4443 SACE_4490 SACE_4513
SVI: 
Svir_18780
AMD: 
AMED_8415
AMN: 
RAM_43205
AMM: 
AMES_8286
PDX: 
Psed_0641
AMI: 
Amir_3767
SESP: 
BN6_44780
MAU: 
Micau_3257
MIL: 
ML5_5136
VMA: 
VAB18032_20965
AMS: 
AMIS_51660 AMIS_8200
ASE: 
ACPL_1152(adhC)
CAI: 
Caci_4165
SNA: 
Snas_1403
MCU: 
HMPREF0573_11666(adh1A)
AYM: 
YM304_27390
 » show all
Taxonomy
Reference
1  [PMID:9202149]
  Authors
Misset-Smits M, van Ophem PW, Sakuda S, Duine JA.
  Title
Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase.
  Journal
FEBS. Lett. 409 (1997) 221-2.
Reference
2  [PMID:9346279]
  Authors
Norin A, Van Ophem PW, Piersma SR, Persson B, Duine JA, Jornvall H.
  Title
Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases--primary structure, conformational modelling and functional correlations.
  Journal
Eur. J. Biochem. 248 (1997) 282-9.
Reference
3  [PMID:12809551]
  Authors
Vogt RN, Steenkamp DJ, Zheng R, Blanchard JS.
  Title
The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase.
  Journal
Biochem. J. 374 (2003) 657-66.
Reference
4  [PMID:17286835]
  Authors
Rawat M, Av-Gay Y
  Title
Mycothiol-dependent proteins in actinomycetes.
  Journal
FEMS. Microbiol. Rev. 31 (2007) 278-92.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
192140-85-5
DBGET integrated database retrieval system