KEGG   ENZYME: 1.1.1.309Help
Entry
EC 1.1.1.309                Enzyme                                 

Name
phosphonoacetaldehyde reductase (NADH);
PhpC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-hydroxyethylphosphonate:NAD+ oxidoreductase
Reaction(IUBMB)
2-hydroxyethylphosphonate + NAD+ = phosphonoacetaldehyde + NADH + H+ [RN:R09478]
Reaction(KEGG)
Substrate
2-hydroxyethylphosphonate [CPD:C06451];
NAD+ [CPD:C00003]
Product
phosphonoacetaldehyde [CPD:C03167];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate. The preferred cofactor is NADH, lower activity with NADPH [1].
History
EC 1.1.1.309 created 2011
Pathway
Phosphonate and phosphinate metabolism
Biosynthesis of antibiotics
Orthology
K12904  
phosphonoacetaldehyde reductase
Reference
1  [PMID:17632514]
  Authors
Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW
  Title
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.
  Journal
Nat. Chem. Biol. 3 (2007) 480-5.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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