KEGG   ENZYME: 1.1.1.310Help
Entry
EC 1.1.1.310                Enzyme                                 

Name
(S)-sulfolactate dehydrogenase;
(2S)-3-sulfolactate dehydrogenase;
SlcC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S)-sulfolactate:NAD+ oxidoreductase
Reaction(IUBMB)
(2S)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+ [RN:R05693]
Reaction(KEGG)
Substrate
(2S)-3-sulfolactate [CPD:C11499];
NAD+ [CPD:C00003]
Product
3-sulfopyruvate [CPD:C05528];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 1.1.1.338, (2R)-3-sulfolactate dehydrogenase (NADP+), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24, (2R)-sulfolactate sulfo-lyase.
The enzyme is specific for NAD+.
History
EC 1.1.1.310 created 2011, modified 2013
Pathway
Cysteine and methionine metabolism
Orthology
K16843  
(S)-sulfolactate dehydrogenase
Genes
CSA: 
RPJ: 
REU: 
CTI: 
CBW: 
CGD: 
CR3_0183(slcC)
BXE: 
BXB: 
PTX: 
BPT: 
Bpet0409(serA2)
AXY: 
AXYL_00471(serA1)
AXO: 
AXN: 
AXS: 
AXX: 
ADT: 
AKA: 
AMIM: 
MIM_c37610(serA2)
VEI: 
VAP: 
VPD: 
HAR: 
ADE: 
ACP: 
AFW: 
ANK: 
OCA: 
OCG: 
OCO: 
BOP: 
MRD: 
MET: 
MOR: 
RVA: 
FIL: 
FIY: 
DSH: 
Dshi_1001(serA2)
RSU: 
AZL: 
ALI: 
ATI: 
DKU: 
DRU: 
TMR: 
SAP: 
SNA: 
CAP: 
MRB: 
MSV: 
 » show all
Taxonomy
Reference
1  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology. 156 (2010) 967-74.
  Sequence
[csa:Csal_1770]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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