KEGG   ENZYME: 1.1.1.312Help
Entry
EC 1.1.1.312                Enzyme                                 

Name
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase;
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase;
4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase;
alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase;
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase;
LigC;
ProD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase
Reaction(IUBMB)
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+ [RN:R04279]
Reaction(KEGG)
Substrate
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal;
NADP+ [CPD:C00006]
Product
2-oxo-2H-pyran-4,6-dicarboxylate;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].
History
EC 1.1.1.312 created 1978 as EC 1.2.1.45, transferred 2011 to EC 1.1.1.312
Pathway
ec00350  Tyrosine metabolism
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
Orthology
K10219  2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
Genes
VNA: PN96_18475
VEJ: VEJY3_18041
VFL: AL536_10275
PAT: Patl_3884
AAW: AVL56_08855
CSA: Csal_0286
MMW: Mmwyl1_3923
MME: Marme_0839
MPC: Mar181_0387
GSN: YC6258_04095
BPH: Bphy_3203
RFR: Rfer_0329
PNA: Pnap_2026
ACRA: BSY15_1203
VEI: Veis_0171
DAC: Daci_4444
CTES: O987_16255
RTA: Rta_24750
LIM: L103DPR2_01499(ligC)
LIH: L63ED372_01146(ligC)
HYB: Q5W_10735
CBAA: SRAA_1349
CBAB: SMCB_0796
LCH: Lcho_3638
AZO: azo2536(ligC)
AOA: dqs_2693
TCL: Tchl_1063
BRA: BRADO2343(ligC)
BBT: BBta_2703(ligC)
AOL: S58_52560
BRO: BRAD285_4994(ligC)
RPA: RPA4703(ligC)
RPB: RPB_0871
RPD: RPD_0981
RPE: RPE_0752
RPT: Rpal_5184
MALG: MALG_02288
NAR: Saro_2811
SMAZ: LH19_17685
SPHI: TS85_18525
SSAN: NX02_17495
SSY: SLG_12490(ligC)
SPHB: EP837_03495(ligC)
SPHR: BSY17_3445
SFLA: SPHFLASMR4Y_02989(ligC)
BLAS: BSY18_3525
AAY: WYH_01910(ligC)
ADO: A6F68_01078(ligC)
MAG: amb0255
MAGX: XM1_1092(ligC)
MAGN: WV31_13620
ABS: AZOBR_p310194(ligC)
MAGQ: MGMAQ_2671(ligC)
SLAU: SLA_7099
KSK: KSE_75130(pcmB)
AMIN: AUMI_19370
ART: Arth_4372
 » show all
Taxonomy
Reference
1  [PMID:26671]
  Authors
Maruyama K, Ariga N, Tsuda M, Deguchi K.
  Title
Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase.
  Journal
J. Biochem. (Tokyo). 83 (1978) 1125-34.
Reference
2  [PMID:528534]
  Authors
Maruyama K
  Title
Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase.
  Journal
J. Biochem. 86 (1979) 1671-7.
Reference
3  [PMID:6841353]
  Authors
Maruyama K.
  Title
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
  Journal
J. Biochem. (Tokyo). 93 (1983) 557-65.
Reference
4  [PMID:11073908]
  Authors
Masai E, Momose K, Hara H, Nishikawa S, Katayama Y, Fukuda M
  Title
Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6.
  Journal
J. Bacteriol. 182 (2000) 6651-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.312
IUBMB Enzyme Nomenclature: 1.1.1.312
ExPASy - ENZYME nomenclature database: 1.1.1.312
BRENDA, the Enzyme Database: 1.1.1.312

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