KEGG   ENZYME: 1.1.1.313Help
Entry
EC 1.1.1.313                Enzyme                                 

Name
sulfoacetaldehyde reductase;
isfD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isethionate:NADP+ oxidoreductase
Reaction(IUBMB)
isethionate + NADP+ = 2-sulfoacetaldehyde + NADPH + H+ [RN:R02600]
Reaction(KEGG)
Substrate
isethionate [CPD:C05123];
NADP+ [CPD:C00006]
Product
2-sulfoacetaldehyde [CPD:C00593];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyse this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells.
History
EC 1.1.1.313 created 2011
Pathway
Taurine and hypotaurine metabolism
Metabolic pathways
Orthology
K15373  
sulfoacetaldehyde reductase
Genes
ENR: 
ENF: 
KPN: 
KPU: 
KPM: 
KPP: 
KPK: 
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KPZ: 
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KVQ: 
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DDA: 
VNA: 
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PFV: 
PSA: 
PSZ: 
PSR: 
PSC: 
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PSTT: 
PBM: 
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AVN: 
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AVD: 
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MSR: 
SSAL: 
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HCS: 
HAK: 
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 » show all
Taxonomy
Reference
1  [PMID:20133363]
  Authors
Krejcik Z, Hollemeyer K, Smits TH, Cook AM
  Title
Isethionate formation from taurine in Chromohalobacter salexigens: purification of sulfoacetaldehyde reductase.
  Journal
Microbiology. 156 (2010) 1547-55.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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